{"title":"The neurobiology of thirst and salt appetite.","authors":"James C R Grove, Zachary A Knight","doi":"10.1016/j.neuron.2024.10.028","DOIUrl":null,"url":null,"abstract":"<p><p>The first act of life was the capture of water within a cell membrane,<sup>1</sup> and maintaining fluid homeostasis is critical for the survival of most organisms. In this review, we discuss the neural mechanisms that drive animals to seek out and consume water and salt. We discuss the cellular and molecular mechanisms for sensing imbalances in blood osmolality, volume, and sodium content; how this information is integrated in the brain to produce thirst and salt appetite; and how these motivational drives are rapidly quenched by the ingestion of water and salt. We also highlight some of the gaps in our current understanding of the fluid homeostasis system, including the molecular identity of the key sensors that detect many fluid imbalances, as well as the mechanisms that control drinking in the absence of physiologic deficit, such as during meals.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3999-4016"},"PeriodicalIF":14.7000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuron","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neuron.2024.10.028","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/27 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The first act of life was the capture of water within a cell membrane,1 and maintaining fluid homeostasis is critical for the survival of most organisms. In this review, we discuss the neural mechanisms that drive animals to seek out and consume water and salt. We discuss the cellular and molecular mechanisms for sensing imbalances in blood osmolality, volume, and sodium content; how this information is integrated in the brain to produce thirst and salt appetite; and how these motivational drives are rapidly quenched by the ingestion of water and salt. We also highlight some of the gaps in our current understanding of the fluid homeostasis system, including the molecular identity of the key sensors that detect many fluid imbalances, as well as the mechanisms that control drinking in the absence of physiologic deficit, such as during meals.
期刊介绍:
Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.