Dysregulated HPA axis during postnatal developmental stages in the BTBR T+ Itpr3tf/J mouse: A model of autism spectrum disorder.

IF 2 Q3 NEUROSCIENCES
Neuropsychopharmacology Reports Pub Date : 2025-03-01 Epub Date: 2024-11-28 DOI:10.1002/npr2.12508
Nozomi Endo, Atsuo Hiraishi, Sayaka Goto, Hitoshi Nozu, Takayo Mannari-Sasagawa, Noriko Horii-Hayashi, Michiko Kitsuki, Mamiko Okuda, Manabu Makinodan, Mayumi Nishi
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Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Some children with ASD show enhanced cortisol response to stress. BTBR T+ Itpr3tf/J (BTBR) mice, an ASD model, display behavior consistent with the three diagnostic categories of ASD and exhibit an exaggerated response to stress in adulthood. However, it remains unclear how basal corticosterone levels change and how the hypothalamic-pituitary-adrenal axis responds to stress during the early life stages in BTBR mice. In this study, we found that basal corticosterone levels showed characteristic changes, peaking at weaning during postnatal development in both BTBR and control C57BL/6J (B6J) mice. Furthermore, we observed higher corticosterone and corticotropin-releasing hormone levels in BTBR mice than in B6J mice following acute stress exposure during weaning; however, adrenocorticotropic hormone levels were lower in BTBR mice. Glucocorticoid receptor mRNA expression levels in the hippocampus and lateral septum after stress were higher in BTBR mice than in B6J mice. This study documented changes in corticosterone levels at baseline during postnatal development in mice and showed that BTBR mice exhibited disrupted stress responses at weaning.

BTBR T+ Itpr3tf/J小鼠出生后发育阶段HPA轴异常:自闭症谱系障碍模型
自闭症谱系障碍(ASD)是一种神经发育障碍。一些自闭症儿童对压力的皮质醇反应增强。BTBR T+ Itpr3tf/J (BTBR)小鼠是一种ASD模型,其表现出与ASD的三种诊断类别一致的行为,并且在成年期表现出对压力的夸张反应。然而,在BTBR小鼠的早期生活阶段,基底皮质酮水平如何变化以及下丘脑-垂体-肾上腺轴如何对压力作出反应尚不清楚。在这项研究中,我们发现BTBR和对照C57BL/6J (B6J)小鼠的基础皮质酮水平出现特征性变化,在产后发育期间断奶时达到峰值。此外,我们观察到在断奶期间急性应激暴露后,BTBR小鼠的皮质酮和促肾上腺皮质激素释放激素水平高于B6J小鼠;然而,BTBR小鼠的促肾上腺皮质激素水平较低。应激后BTBR小鼠海马和侧隔糖皮质激素受体mRNA表达水平高于B6J小鼠。本研究记录了小鼠出生后发育期间皮质酮水平的基线变化,并表明BTBR小鼠在断奶时表现出中断的应激反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neuropsychopharmacology Reports
Neuropsychopharmacology Reports Psychology-Clinical Psychology
CiteScore
3.60
自引率
4.00%
发文量
75
审稿时长
14 weeks
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