Histologic Effects of Fractional Lasers and Energy-Based Devices on Intradermally Injected Hyaluronic Acid Filler for Improving Skin Smoothness.

IF 2.2 3区 医学 Q2 DERMATOLOGY
Shealinna Ge, Hye Jin Chung, Robert A Weiss
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引用次数: 0

Abstract

Background: Prior studies have shown that energy-based devices (EBDs) over pre-injected hyaluronic acid (HA) fillers do not significantly affect clinical outcomes. However, the impact of EBDs over newly FDA-approved HA filler for improving skin smoothness is still undetermined.

Objective: To evaluate the immediate histologic changes after various popular EBDs are performed over pre-injected, newly FDA-approved intradermal HA filler.

Materials and methods: Abdominoplasty skin was injected with HA superficially. Zone 1 was used as untreated control, while the other zones treated with the 755-nm picosecond laser with diffractive lens array, 1064-nm picosecond and 1064-nm Q-switched lasers, radiofrequency with insulated microneedles, volumetric directional thermal impact ultrasound (VDTI), and thermomechanical fractional injury (TMFI) devices.

Results: Histology shows HA in the superficial to mid dermis. Treatment with fractional Q-switched and picosecond lasers showed expected laser-induced optical breakdown in the epidermis and dermis. RF microneedling, VDTI, and TMFI devices caused thermal damage of collagen bundles with dermal dehydration.

Conclusion: No immediate morphological changes to HA were noted following device treatment. However, the effect of heat-generating devices on the molecular integrity of HA fillers, which are composed of HA and water, remains uncertain.

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来源期刊
CiteScore
5.40
自引率
12.50%
发文量
119
审稿时长
1 months
期刊介绍: Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.
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