Histologic Effects of Fractional Lasers and Energy-Based Devices on Intradermally Injected Hyaluronic Acid Filler for Improving Skin Smoothness

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2024-11-29 DOI:10.1002/lsm.23863

Shealinna Ge, Hye Jin Chung, Robert A. Weiss

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引用次数: 0

Abstract

Background

Prior studies have shown that energy-based devices (EBDs) over pre-injected hyaluronic acid (HA) fillers do not significantly affect clinical outcomes. However, the impact of EBDs over newly FDA-approved HA filler for improving skin smoothness is still undetermined.

Objective

To evaluate the immediate histologic changes after various popular EBDs are performed over pre-injected, newly FDA-approved intradermal HA filler.

Materials and Methods

Abdominoplasty skin was injected with HA superficially. Zone 1 was used as untreated control, while the other zones treated with the 755-nm picosecond laser with diffractive lens array, 1064-nm picosecond and 1064-nm Q-switched lasers, radiofrequency with insulated microneedles, volumetric directional thermal impact ultrasound (VDTI), and thermomechanical fractional injury (TMFI) devices.

Results

Histology shows HA in the superficial to mid dermis. Treatment with fractional Q-switched and picosecond lasers showed expected laser-induced optical breakdown in the epidermis and dermis. RF microneedling, VDTI, and TMFI devices caused thermal damage of collagen bundles with dermal dehydration.

Conclusion

No immediate morphological changes to HA were noted following device treatment. However, the effect of heat-generating devices on the molecular integrity of HA fillers, which are composed of HA and water, remains uncertain.

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分数激光和能量装置对皮内注射透明质酸填充剂改善皮肤光滑的组织学影响。

背景：先前的研究表明，能量基装置（EBDs）优于预注射透明质酸（HA）填充剂对临床结果没有显著影响。然而，ebd对fda新批准的HA填料改善皮肤光滑的影响仍未确定。目的：评价各种流行的EBDs与fda新批准的皮内HA填充剂预注射后的即时组织学变化。材料与方法：腹腔成形术皮肤表面注射透明质酸。第1区作为未处理的对照组，其余区域分别使用755 nm皮秒衍射透镜阵列激光、1064 nm皮秒和1064 nm调q激光、绝缘微针射频、体积定向热冲击超声（VDTI）和热机械分数损伤（TMFI）装置进行治疗。结果：组织学显示HA位于真皮浅层至中层。分数调q和皮秒激光治疗在表皮和真皮中显示出预期的激光诱导光学击穿。射频微针、VDTI和TMFI装置引起皮肤脱水的胶原束热损伤。结论：器械治疗后HA没有立即形态学改变。然而，产热装置对HA和水组成的HA填料分子完整性的影响仍不确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.