A reactive oxygen species-related signature predicts the prognosis and immunosuppressive microenvironment in gliomas.

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Redox Report Pub Date : 2024-12-01 Epub Date: 2024-11-28 DOI:10.1080/13510002.2024.2433396

Xia Shan, Ruoyu Huang, Kuanyu Wang, Pei Yang

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引用次数: 0

Abstract

Objective: Intracellular redox homeostasis is crucial for a series of physiological processes. Reactive oxygen species (ROS) play important roles in redox processes. ROS can maintain cell reproduction and survival at moderate levels while promoting the initiation and progression of tumors at high levels.

Methods: Based on a comprehensive analysis of ROS-related gene expression profiles, we established a gene signature associated with ROS to explore its influence on prognosis and immune microenvironment in gliomas.

Results: The ROS-related gene expression profile dichotomized patients into two groups with different clinicopathological features and prognoses. A 19-gene ROS-related signature was used to robustly predict prognosis in both training and validation datasets. Functional analysis indicated an association between ROS levels and the immune microenvironment. The expression of immune checkpoints and M2-type markers was upregulated in the high-risk group, which suggested the immunosuppressive function of ROS.

Conclusion: ROS-related signature is an independent prognostic factor in gliomas and could potentially exert immunosuppressive effects on the tumor microenvironment.

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一个与活性氧相关的标记可以预测胶质瘤的预后和免疫抑制微环境。

目的：细胞内氧化还原稳态对一系列生理过程至关重要。活性氧（ROS）在氧化还原过程中起着重要作用。ROS可以在中等水平上维持细胞的繁殖和存活，而在高水平上促进肿瘤的发生和发展。方法：在综合分析ROS相关基因表达谱的基础上，建立与ROS相关的基因标记，探讨其对胶质瘤预后和免疫微环境的影响。结果：ros相关基因表达谱将患者分为两组，具有不同的临床病理特征和预后。在训练和验证数据集中，19个基因ros相关特征被用于可靠地预测预后。功能分析表明ROS水平与免疫微环境之间存在关联。高危组免疫检查点和m2型标记物表达上调，提示ROS具有免疫抑制功能。结论：ros相关信号是胶质瘤的独立预后因素，可能对肿瘤微环境产生免疫抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.