The risk factors and prognostic impact of different benign pathologic types of background endometrium surrounding endometrial polyps

IF 2.6 3区医学 Q2 OBSTETRICS & GYNECOLOGY

International Journal of Gynecology & Obstetrics Pub Date : 2024-11-29 DOI:10.1002/ijgo.16067

Jiezhuang Huang, Yuxin Li, Peiyue Chen, Zhifu Zhi

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引用次数: 0

Abstract

Objective

This retrospective study investigated the prognostic significance and risk factors of benign pathologic types of background endometrium surrounding endometrial polyps (EPs).

Methods

We assessed 206 patients who underwent hysteroscopic polypectomy and background endometrium biopsy. Patients were categorized into four groups based on the pathologic types of background endometrium: normal proliferative endometrium (NPE), polypoid hyperplastic endometrium (PHE), chronic endometritis (CE), and non-atypical endometrial hyperplasia (NEH). We employed univariable comparisons and multivariable logistic regression analysis to identify risk factors of PHE, CE, and NEH compared to NPE. Abnormal uterine bleeding (AUB) and recurrence of EPs were monitored over a 12-month postoperative follow-up period.

Results

Independent risk factors for EPs with a background of CE included a history of genital tract infection (OR = 8.88, 95% CI: 2.95–26.70, P = 0.000), adenomyosis (OR = 13.70, 95% CI: 3.38–55.52, P = 0.000), and hydrosalpinx (OR = 2.23, 95% CI: 1.59–54.09, P = 0.013). Age (OR = 1.18, 95% CI: 1.07–1.30, P = 0.001) and BMI (OR = 1.33, 95% CI: 1.11–1.61, P = 0.003) were significant risk factors for EPs with a background of NEH. Patients with PHE had higher recurrence rates of EPs following 12 months of follow-up. Moreover, background endometrium types PHE, CE, and NEH were associated with poorer control of AUB.

Conclusion

Our study underscores the importance of examining the histopathologic characteristics of the background endometrium surrounding EPs, as these benign lesions significantly influence the recurrence and symptomatology of EPs.

查看原文本刊更多论文

子宫内膜息肉周围不同良性病理类型的危险因素及对预后的影响。

目的：回顾性研究子宫内膜息肉（EPs）周围背景子宫内膜良性病理类型的预后意义及危险因素。方法：我们对206例接受宫腔镜息肉切除术和背景子宫内膜活检的患者进行评估。根据背景子宫内膜的病理类型将患者分为四组：正常增殖性子宫内膜（NPE）、息肉样增生性子宫内膜（PHE）、慢性子宫内膜炎（CE）和非典型子宫内膜增生（NEH）。我们采用单变量比较和多变量logistic回归分析来确定与NPE相比PHE、CE和NEH的危险因素。术后随访12个月，监测子宫异常出血（AUB）和EPs复发情况。结果：有CE背景的EPs的独立危险因素包括生殖道感染史（OR = 8.88, 95% CI: 2.95 ~ 26.70, P = 0.000）、子宫腺肌症（OR = 13.70, 95% CI: 3.38 ~ 55.52, P = 0.000）和输卵管积水（OR = 2.23, 95% CI: 1.59 ~ 54.09, P = 0.013）。年龄（OR = 1.18, 95% CI: 1.07-1.30, P = 0.001）和BMI （OR = 1.33, 95% CI: 1.11-1.61, P = 0.003）是伴有NEH背景的EPs的重要危险因素。PHE患者在随访12个月后EPs复发率较高。此外，背景子宫内膜类型PHE、CE和NEH与AUB控制较差相关。结论：我们的研究强调了检查EPs周围背景子宫内膜的组织病理学特征的重要性，因为这些良性病变显著影响EPs的复发和症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Gynecology & Obstetrics 医学-妇产科学

CiteScore

5.80

自引率

2.60%

发文量

493

审稿时长

3-6 weeks

期刊介绍： The International Journal of Gynecology & Obstetrics publishes articles on all aspects of basic and clinical research in the fields of obstetrics and gynecology and related subjects, with emphasis on matters of worldwide interest.