The impact of substituting clarified butter with canola oil on the components of metabolic syndrome, fatty liver index, and insulin resistance among individuals diagnosed with metabolic syndrome: a quasi-experimental study.

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2024-06-19 eCollection Date: 2024-12-01 DOI:10.1007/s40200-024-01453-z

Fatemeh Maleki Sedgi, Mohammadreza Mohammad Hosseiniazar, Mohammad Alizadeh

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引用次数: 0

Abstract

Purpose: Clarified butter, contain harmful saturated and beneficial trans-fatty acids. Canola oil is a promising alternative to other oils for reducing saturated fat intake. This trial aimed to investigate the effects of replacing clarified butter with canola oil in patients with metabolic syndrome on various metabolic syndrome components, fatty liver index (FLI), and insulin resistance.

Methods: In this trial, 42 individuals with metabolic syndrome referred to the clinic in Imam Khomeini University Hospital in Urmia, Iran, were enrolled. The participants, who commonly consumed (3 to 8 serving per day) clarified butter, were instructed to follow a healthy diet and replace their consumption of clarified butter with an equivalent amount of canola oil for 3 months. To compare the differences of outcomes in the group, the paired samples T-test and cohen's d effect size were applied. To analyze the changes in dietary intakes and Metabolic equivalent of task (MET), repeated measures of ANOVA was used.

Results: There was a significant decrease in fasting blood sugar (FBS) (< 0.001), triglyceride (TG) (0.003), and anthropometric measurements (< 0.001). Furthermore, significant reductions were observed in total cholesterol (TC) (< 0.001), low-density lipoprotein (LDL) (0.009), gamma-glutamyl transferase (GGT) levels (0.003), FLI (< 0.001), insulin levels (0.007), and homeostatic model assessment for insulin resistance (HOMA-IR) (0.002), and increase in quantitative insulin-sensitivity check index (QUICKI) (< 0.001). Unfavorably, there was a significant reduction in the high-density lipoprotein (HDL) (< 0.001).

Conclusion: The replacement of clarified butter with canola oil demonstrated potential benefits in improving metabolic syndrome.

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-024-01453-z.

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菜籽油替代澄清黄油对代谢综合征患者代谢综合征成分、脂肪肝指数和胰岛素抵抗的影响：一项准实验研究

用途：澄清黄油，含有有害的饱和脂肪酸和有益的反式脂肪酸。菜籽油是减少饱和脂肪摄入的一种很有前途的油替代品。本试验旨在探讨用菜籽油替代澄清黄油对代谢综合征患者各种代谢综合征成分、脂肪肝指数（FLI）和胰岛素抵抗的影响。方法：在这项试验中，42例代谢综合征患者被纳入伊朗乌尔米娅伊玛目霍梅尼大学医院的临床。经常食用（每天3到8份）澄清黄油的参与者被指示遵循健康饮食，用等量的菜籽油代替他们食用的澄清黄油，为期3个月。为了比较各组结果的差异，采用配对样本t检验和cohen's d效应量。为了分析饮食摄入量和任务代谢当量（MET）的变化，使用了重复方差分析。结果：空腹血糖（FBS）明显降低(结论：用菜籽油代替澄清黄油对改善代谢综合征有潜在的好处。补充信息：在线版本提供补充资料，网址为10.1007/s40200-024-01453-z。

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.