Albizia ferruginea (Guill. & Perr.) Benth. leaf abates deregulation of P53, IRS, HsD17β2, FTO, and CYP11a genes in polycystic ovarian syndrome rat.

Q2 Medicine

Journal of Complementary and Integrative Medicine Pub Date : 2024-11-29 eCollection Date: 2025-03-01 DOI:10.1515/jcim-2024-0287

Akingbolabo Daniel Ogunlakin, Meek Oyinlola Meruwoma, Princewill Obinna Ihiasota, Oluwafemi Adeleke Ojo, Adeyemi Abdullahi Adegoke, Idayat Adeola Akinwumi, Owoola Azeezat Ambali, Oyindamola Esther Awosola, Mubo Adeola Sonibare

{"title":"Albizia ferruginea (Guill. & Perr.) Benth. leaf abates deregulation of P53, IRS, HsD17β2, FTO, and CYP11a genes in polycystic ovarian syndrome rat.","authors":"Akingbolabo Daniel Ogunlakin, Meek Oyinlola Meruwoma, Princewill Obinna Ihiasota, Oluwafemi Adeleke Ojo, Adeyemi Abdullahi Adegoke, Idayat Adeola Akinwumi, Owoola Azeezat Ambali, Oyindamola Esther Awosola, Mubo Adeola Sonibare","doi":"10.1515/jcim-2024-0287","DOIUrl":null,"url":null,"abstract":"Objectives: This study investigated the potential ameliorative effects of Albizia ferruginea leaves on letrozole-induced polycystic ovarian syndrome (PCOS) in Wistar rats.Methods: PCOS was induced in 25 female Wistar rats by administering letrozole (1 mg/kg), followed by treatment with 100 and 250 mg/kg body weight A. ferruginea leaf methanolic extract, as well as 1 mg/kg body weight of clomiphene citrate as standard.Results: An acute toxicity study revealed a toxic dosage of 2,000 mg/kg for the plant extract. The A. ferruginea extract exhibited potent hydroxyl radical scavenging ability. Treatment with A. ferruginea leaf extract improved the irregular estrus cycle and hormonal imbalance. Additionally, the extract administration led to decreased testosterone and increased estradiol levels when compared to the untreated PCOS rat. Furthermore, methanol extract normalizes the levels of insulin receptor substrate (IRS), type 2 17-HSD (HsD17β2), P53, 11a-hydroxylase/17,20-desmolase (CYP11a), and fat mass and obesity-associated (FTO), genes in the cervix of PCOS rats.Conclusions: Overall, A. ferruginea demonstrated beneficial properties on polycystic ovary circumstances in rats, presenting its potential as a promising treatment for PCOS.","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"124-133"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Complementary and Integrative Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/jcim-2024-0287","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: This study investigated the potential ameliorative effects of Albizia ferruginea leaves on letrozole-induced polycystic ovarian syndrome (PCOS) in Wistar rats.

Methods: PCOS was induced in 25 female Wistar rats by administering letrozole (1 mg/kg), followed by treatment with 100 and 250 mg/kg body weight A. ferruginea leaf methanolic extract, as well as 1 mg/kg body weight of clomiphene citrate as standard.

Results: An acute toxicity study revealed a toxic dosage of 2,000 mg/kg for the plant extract. The A. ferruginea extract exhibited potent hydroxyl radical scavenging ability. Treatment with A. ferruginea leaf extract improved the irregular estrus cycle and hormonal imbalance. Additionally, the extract administration led to decreased testosterone and increased estradiol levels when compared to the untreated PCOS rat. Furthermore, methanol extract normalizes the levels of insulin receptor substrate (IRS), type 2 17-HSD (HsD17β2), P53, 11a-hydroxylase/17,20-desmolase (CYP11a), and fat mass and obesity-associated (FTO), genes in the cervix of PCOS rats.

Conclusions: Overall, A. ferruginea demonstrated beneficial properties on polycystic ovary circumstances in rats, presenting its potential as a promising treatment for PCOS.

查看原文本刊更多论文

铁锈Albizia ferruginea&穗青葱)。Benth。在多囊卵巢综合征大鼠中，叶能减弱P53、IRS、HsD17β2、FTO和CYP11a基因的失调。

目的：探讨铁皮合欢叶对来曲唑诱导的Wistar大鼠多囊卵巢综合征的潜在改善作用。方法：用来曲唑（1 mg/kg）诱导25只雌性Wistar大鼠多囊卵巢综合征（PCOS），然后分别用100和250 mg/kg体重的铁铁甲叶甲醇提取物和1 mg/kg体重的枸橼酸克罗米芬作为对照。结果：急性毒性研究显示，该植物提取物的毒性剂量为2,000 mg/kg。铁杉提取物具有较强的羟基自由基清除能力。铁铁花叶提取物改善了发情周期不规律和激素失衡。此外，与未治疗的PCOS大鼠相比，提取物管理导致睾酮降低和雌二醇水平升高。此外，甲醇提取物使PCOS大鼠子宫颈胰岛素受体底物（IRS）、2型17- hsd （hsd17 - β2）、P53、11a-羟化酶/17,20-去糖化酶（CYP11a）和脂肪质量和肥胖相关（FTO）基因水平正常化。结论：综上所述，铁铁花对大鼠多囊卵巢有一定的治疗作用，具有治疗多囊卵巢的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Complementary and Integrative Medicine Medicine-Complementary and Alternative Medicine

CiteScore

3.10

自引率

0.00%

发文量

期刊介绍： Journal of Complementary and Integrative Medicine (JCIM) focuses on evidence concerning the efficacy and safety of complementary medical (CM) whole systems, practices, interventions and natural health products, including herbal and traditional medicines. The journal is edited by Ed Lui of the University of Western Ontario. Topics: -Quality, efficacy, and safety of natural health products, dietary supplements, traditional medicines and their synthetic duplicates -Efficacy and safety of complementary therapies -Evidence-based medicine and practice, including evidence of traditional use -Curriculum development, educational system and competency of complementary health programs -Methodologies on research and evaluation of traditional medicines and herbal products -Integrative medicine: basic and clinical research and practice -Innovation in CAM Curriculum -Educational Material Design