Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study.

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI:10.1177/13872877241302350

Minos Kritikos, Juin-Wan Zhou, Chuan Huang, Sam Gandy, Alison C Pellecchia, Stephanie Santiago-Michels, Melissa A Carr, Shabab Islam, Yuan Yang, Megan K Horton, Roberto G Lucchini, Ana M Franceschi, Lev Bangiyev, Paul Vaska, Sean Ap Clouston, Benjamin J Luft

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引用次数: 0

Abstract

Background: Amyloid-β proteins, a hallmark of Alzheimer's disease, are believed to play an adaptive role in the cerebral immune response.

Objective: Amyloid is believed to play a role in cerebral immune response and could play a similar role in response to air pollution exposures. In the present study, we examined whether WTC exposure duration was associated with cerebral amyloidosis in WTC responders.

Methods: WTC responders (aged 44-65 years) who varied in exposure duration but did not use personalized protective equipment were assessed using positron-emission tomography with [¹⁸F]-Florbetaben. The outcome was the cortical [¹⁸F]-Florbetaben burden, measured using regional standardized uptake value ratios (SUVRs) in 34 Desikan-Killiany regions of interest. Spearman's ρ and generalized linear models were used to estimate correlations between WTC exposure duration and cortical [¹⁸F]-Florbetaben SUVR. Cognitive and behavioral symptoms were measured. Magnetic resonance imaging was used to measure cortical thickness and diffusivity.

Results: The mean age of imaged responders was 56 years old. WTC exposure duration was associated with olfactory [¹⁸F]-Florbetaben SUVR (Spearman's ρ = 0.43, p = 0.011), which was in turn associated with elevated [¹⁸F]-Florbetaben SUVR in ventral regions (ρ = 0.41, p = 0.016). Cortical [¹⁸F]-Florbetaben in ventral regions was associated with reduced response speed (ρ = -0.72, p < 0.001), was co-located with cortical diffusivity across regions in the parietal and frontal lobes and reduced cortical thickness in the isthmus cingulate (ρ = -0.53, p = 0.001).

Conclusions: Low-grade amyloidosis in the olfactory and frontal lobes was associated with WTC exposure duration. Future work should examine whether low-grade amyloidosis is correlated with the location or distribution of neurofibrillary tangles in WTC responders.

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世贸中心响应者嗅皮质暴露时间与大脑淀粉样变性：正电子发射断层扫描和磁共振成像研究。

背景：淀粉样蛋白-β是阿尔茨海默病的标志，被认为在大脑免疫反应中发挥适应性作用。目的：淀粉样蛋白被认为在大脑免疫反应中发挥作用，并可能在空气污染暴露中发挥类似的作用。在本研究中，我们研究了WTC暴露时间是否与WTC应答者的脑淀粉样变性有关。方法：使用[18F]-Florbetaben正电子发射断层扫描对暴露时间不同但未使用个性化防护设备的WTC应答者（44-65岁）进行评估。结果是皮质[18F]-Florbetaben负荷，在34个感兴趣的Desikan-Killiany区域使用区域标准化摄取值比（SUVRs）测量。Spearman ρ和广义线性模型用于估计WTC暴露时间与皮质[18F]-Florbetaben SUVR之间的相关性。测量认知和行为症状。磁共振成像测量皮质厚度和扩散系数。结果：影像学应答者的平均年龄为56岁。WTC暴露时间与嗅觉[18F]-Florbetaben SUVR相关（Spearman’s ρ = 0.43, p = 0.011），而嗅觉[18F]-Florbetaben SUVR又与腹侧区域[18F]-Florbetaben SUVR升高相关（ρ = 0.41, p = 0.016）。腹侧皮质区[18F]-Florbetaben与反应速度降低相关（ρ = -0.72, p ρ = -0.53, p = 0.001）。结论：嗅觉和额叶的低级别淀粉样变性与WTC暴露时间有关。未来的工作应该研究低级别淀粉样变性是否与WTC应答者中神经原纤维缠结的位置或分布有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.