Cerebral magnetic resonance spectroscopy - insights into preterm brain injury.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2024-11-28 DOI:10.1038/s41372-024-02172-2

Magdalena Zasada, Paulina Karcz, Marta Olszewska, Aleksandra Kowalik, Wojciech Zasada, Izabela Herman-Sucharska, Przemko Kwinta

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Abstract

Objective: Magnetic resonance spectroscopy (¹H-MRS) may provide clinically relevant data regarding metabolic processes that govern the course of preterm brain injury.

Study design: 46 very preterm infants (VP) were evaluated by magnetic resonance imaging and ¹H-MRS at term-equivalent age. Brain injury was assessed according to the Kidokoro scale. Moreover, 17 term-born infants with hypoxic-ischemic encephalopathy (HIE) were scanned. The metabolic profile of the central nervous system was obtained from the bilateral thalamus.

Result: The Lipids/Creatine, Choline/Creatine, N-acetyl aspartate/Choline, Lactate/N-acetyl aspartate, and Lactate/Creatine ratios differed between VP infants with moderate+severe brain damage and those without brain injury. Moreover, VP infants with moderate+severe brain damage had higher Lactate/ N-acetyl aspartate and Lactate/Creatine ratios than HIE group.

Conclusion: There were significant differences in the cerebral metabolite profile at TEA between VP infants with and without brain injury. The ¹H-MRS profile of VP infants with moderate+severe brain damage may reflect profound chronic metabolic alterations.

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.