Megaoesophagus associated to inflammatory infiltrate in the autonomous plexus in a 7-year-old Spanish Water Dog.

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
María T Ruiz-Campillo, Guillem Herrera-Torres, Verónica Molina-Hernández, María J Bautista, Diana M Barrero-Torres, Jesús López-Rasero, José Pérez
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Abstract

Background: Megaoesophagus (ME), a disorder of the oesophagus characterized by diffuse oesophageal dilation and decreased peristalsis that may be congenital or acquired. Knowledge regarding the aetiology and prognosis for canine acquired ME is currently limited with most cases being idiopathic, which is a considerable problem to implement an appropriate treatment and a potential better prognosis.

Case presentation: A 7-year-old, neutered, female Spanish Water Dog was evaluated for progressive weight loss, chronic vomiting and regurgitation. The patient did not present other clinical signs. The contrast radiography in the cervical zone revealed oesophageal dilation. Eventually, the endoscopy revealed a marked dilation of the oesophagus. A surgery was conducted to insert a gastrotomy feeding tube. Initially, the patient response to this treatment was positive. However, the vomiting and regurgitation reappeared after 8 days. Due to the grim prognosis the owners elected to euthanize the patient. Necropsy revealed severe oesophageal dilation. The histopathological evaluation revealed moderate erosive catarrhal oesophagitis and gastritis. The skeletal muscular layer of the oesophagus showed moderate angular atrophy of some muscular fibres and a severe infiltrate of lymphocytes with marked tropism to autonomous neuronal bodies, some of which showed severe degenerative changes with absence of Nissl corpuscles, pyknotic nuclei and eosinophilic cytoplasm. The immunohistochemical study revealed that the majority of the infiltrate surrounding neuronal bodies were CD3 + T cells. These findings are consistent with an immune-mediated megaoesophagus.

Conclusions: To the best of our knowledge, this is the first report describing a lymphoplasmacytic infiltrate surrounding the oesophageal myenteric plexus in an adult dog with no other clinical signs or other myopathies. With these results, the authors hope to raise awareness in the diagnostic of canine ME and include an immune-mediated cause that lean to the establishment of appropriate treatment and improve prognosis of this condition.

7岁西班牙水犬的巨食道与自主神经丛炎症浸润有关。
背景:巨食道(ME),一种以弥漫性食管扩张和蠕动减少为特征的食道疾病,可能是先天性的或后天的。目前,关于犬获得性ME的病因和预后的知识有限,大多数病例是特发性的,这对于实施适当的治疗和潜在的更好预后是一个相当大的问题。病例介绍:一只7岁,绝育,雌性西班牙水犬评估进行性体重下降,慢性呕吐和反流。患者未出现其他临床症状。颈区造影显示食道扩张。最后,内窥镜检查显示食道明显扩张。手术插入胃切开饲管。最初,患者对这种治疗的反应是积极的。8天后再次出现呕吐和反流。由于预后不佳,主人选择对病人实施安乐死。尸检显示食管严重扩张。组织病理学检查显示为中度糜烂性卡他性食管炎和胃炎。食道骨骼肌层部分肌肉纤维呈中度角状萎缩,淋巴细胞严重浸润,向自主神经元体有明显的偏向性,其中部分表现为严重的退行性改变,无尼氏小体、核固缩和嗜酸性细胞质。免疫组化结果显示,周围浸润的神经元体以CD3 + T细胞居多。这些发现与免疫介导的巨型食道一致。结论:据我们所知,这是第一次报道在没有其他临床症状或其他肌病的成年狗的食管肌丛周围发生淋巴浆细胞浸润。通过这些结果,作者希望提高对犬ME诊断的认识,并包括免疫介导的原因,以便建立适当的治疗方法并改善该病的预后。
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来源期刊
BMC Veterinary Research
BMC Veterinary Research VETERINARY SCIENCES-
CiteScore
4.80
自引率
3.80%
发文量
420
审稿时长
3-6 weeks
期刊介绍: BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
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