Production of cannabidiol nanoparticles loaded in polyvinylpyrrolidone microparticles by supercritical CO2 assisted atomization and dissolution enhancement effect

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology Pub Date : 2024-11-28 DOI:10.1016/j.apt.2024.104749

Lucia Baldino, Sonia Sarnelli, Ida Palazzo, Mariarosa Scognamiglio, Ernesto Reverchon

引用次数: 0

Abstract

In this work, cannabidiol (CBD) nanoparticles contained in polyvinylpyrrolidone (PVP) microparticles (nano-in-micro system) were produced by supercritical CO₂ assisted atomization (SAA) with the aim of improving CBD bioavailability. The experiments were performed by changing the total concentration of solute PVP + CBD and CBD/PVP mass ratio (R) to understand the effect of these parameters on CBD nanoparticle mean size, measured by a dynamic light scattering operating in a periodic manner. Nanoparticles as small as 33 nm were obtained, protected in PVP microparticles. CBD release tests were carried out to verify the increase in the solubilization rate of CBD nanoparticles: pure CBD powder was completely dissolved in about 240 min; whereas CBD 55 nm nanoparticles were completely released in 20 min.

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超临界CO2辅助雾化和溶出强化法制备聚乙烯吡咯烷酮载大麻二酚纳米颗粒

采用超临界CO2辅助雾化（SAA）法制备了聚乙烯吡咯烷酮（PVP）微颗粒（纳米-微系统）中的大麻二酚（CBD）纳米颗粒，以提高CBD的生物利用度。实验通过改变溶质PVP + CBD的总浓度和CBD/PVP的质量比(R)来了解这些参数对CBD纳米颗粒平均尺寸的影响，并通过周期性的动态光散射来测量。得到了小至33 nm的纳米颗粒，并被PVP微粒保护。通过CBD释放试验验证了CBD纳米颗粒增溶速率的提高：纯CBD粉末在240 min左右完全溶解；而CBD 55 nm纳米颗粒在20 min内完全释放。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Powder Technology 工程技术-工程：化工

CiteScore

9.50

自引率

7.70%

发文量

424

审稿时长

55 days

期刊介绍： The aim of Advanced Powder Technology is to meet the demand for an international journal that integrates all aspects of science and technology research on powder and particulate materials. The journal fulfills this purpose by publishing original research papers, rapid communications, reviews, and translated articles by prominent researchers worldwide. The editorial work of Advanced Powder Technology, which was founded as the International Journal of the Society of Powder Technology, Japan, is now shared by distinguished board members, who operate in a unique framework designed to respond to the increasing global demand for articles on not only powder and particles, but also on various materials produced from them. Advanced Powder Technology covers various areas, but a discussion of powder and particles is required in articles. Topics include: Production of powder and particulate materials in gases and liquids(nanoparticles, fine ceramics, pharmaceuticals, novel functional materials, etc.); Aerosol and colloidal processing; Powder and particle characterization; Dynamics and phenomena; Calculation and simulation (CFD, DEM, Monte Carlo method, population balance, etc.); Measurement and control of powder processes; Particle modification; Comminution; Powder handling and operations (storage, transport, granulation, separation, fluidization, etc.)