Exploring the relationship between ERCC1 polymorphisms and colorectal cancer risk: Insights from an in-depth meta-analysis

IF 0.5 Q4 GENETICS & HEREDITY

Human Gene Pub Date : 2024-11-28 DOI:10.1016/j.humgen.2024.201361

Praveen Kumar Kampalli , Mohan Krishna Ghanta , Henu Kumar Verma , Afroz Alam , Sujatha Peela , LVKS Bhaskar

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Abstract

Introduction

In recent decades, there has been mounting evidence linking Excision repair cross-complementing gene (ERCC1) polymorphisms to colorectal cancer (CRC). According to recent epidemiological research, the ERCC1 polymorphism may have an impact on the incidence of colorectal cancer (CRC). However, there is controversy on ERCC1 genetic variants affecting CRC in these studies. Hence, this meta-analysis study aimed to analyze the link between CRC and ERCC1 gene polymorphism.

Methodology

We looked up information on the impact of ERCC1 genetic variations on CRC development in the Web of Science, PubMed, and Embase. Addressing the risk of colorectal cancer associated with mutations in the ERCC1 gene, no meta-analysis was conducted. Using Stata (version 12.0) applications, we effectively conducted a meta-analysis of thirteen case-control investigations and integrated the pooled odds ratios (ORs) according to a 95 % confidence interval (CI) of the overall and subgroup analysis.

Results

According to our findings, there appears to have been a noteworthy association found between rs3212986 and the risk of CRC in both the allele genetic model (OR 95 % CI = 1:44 (1.21–1.71) and the dominant genetic model (OR 95 % CI = 1:04 (0.93–1.15) for overall CRC.

Conclusion

In conclusion, the results of this meta-analysis showed that rs3212986 polymorphism was significantly associated with colorectal cancer risk, whereas rs11615 polymorphism was not significantly associated with colorectal cancer risk.

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探讨ERCC1多态性与结直肠癌风险之间的关系：来自深入荟萃分析的见解

近几十年来，越来越多的证据表明，切除修复交叉互补基因（ERCC1）多态性与结直肠癌（CRC）有关。最近的流行病学研究表明，ERCC1多态性可能与结直肠癌（CRC）的发病率有关。然而，在这些研究中，对于ERCC1基因变异是否影响结直肠癌存在争议。因此，本荟萃分析研究旨在分析CRC与ERCC1基因多态性之间的联系。方法：我们在Web of Science、PubMed和Embase中查询了ERCC1基因变异对结直肠癌发展的影响。针对与ERCC1基因突变相关的结直肠癌风险，未进行meta分析。使用Stata （version 12.0）应用程序，我们有效地对13例病例对照调查进行了荟萃分析，并根据总体和亚组分析的95%置信区间（CI）整合了合并优势比（ORs）。根据我们的研究结果，rs3212986与CRC风险之间似乎存在显著的关联，无论是等位基因遗传模型(OR 95% CI = 1:44（1.21-1.71）还是显性遗传模型(OR 95% CI = 1:04（0.93-1.15）。结论综上所述，本荟萃分析结果显示rs3212986多态性与结直肠癌风险显著相关，而rs11615多态性与结直肠癌风险无显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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