MWCNTs-Beta-Cyclodextrin-reduced graphene oxide gel based electrochemical sensor for simultaneous detection of dopamine and uric acid in human sweat samples

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2024-11-23 DOI:10.1016/j.carbpol.2024.123060

Muthui Martin Mwaurah , Jayaraman Mathiyarasu , A.M. Vinu Mohan

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引用次数: 0

Abstract

Accurate determination of dopamine (DA) and uric acid (UA) in biological samples is crucial in diagnosing neurodegenerative disorders and gout, respectively. Here we report a highly sensitive and inexpensive, flexible screen-printed sensor for determining DA and UA in sweat samples. Beta-cyclodextrin-based (βCD) composite gel with reduced graphene oxide (rGO) was synthesized by self-polymerization of βCD at an optimum ratio of “good” and “poor solvent”. Multiwall carbon nanotubes (MWCNTs) were incorporated into the composite as a conductive filler. The MWCNTs-βCD-rGO gel provides selective biorecognition of DA and UA at the electrode surface through guest-host interaction. The gels were characterized by XRD, TGA, FTIR, UV–Vis, ¹H NMR, FESEM, XPS and optical microscopy. The flexible printed sensor showed linear DA detection in the range 0.25 to 16 μM with a correlation coefficient (R²) of 0.9890, limit of detection (LoD) of 0.08 μM and sensitivity of 3.63 μA μM⁻¹ cm⁻². Similarly, UA calibration showed linear detection from 50 to 700 μM with a R² value of 0.9860, LoD of 0.078 μM and sensitivity of 0.118 μA μM⁻¹ cm⁻². The SPE/MWCNTs-βCD-rGOsensor showed simultaneous determination of DA and UA from exercise induced sweat samples. The proposed sensor demonstrated excellent repeatability and satisfactory recoveries in human sweat.

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.