Vahid Ansari , Philippe Massonnet , Hongjuan Weng , Maria Kalogeropoulou , Ron M.A. Heeren , Jules A.W. Harings , Lorenzo Moroni , Katrien V. Bernaerts
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引用次数: 0
Abstract
α-Amino acid based polyester amides (AA-PEAs) exhibit remarkable properties, including biocompatibility, biodegradability, flexibility, thermal stability, and mechanical integrity. The incorporation of α-amino acids enhances cytocompatibility, hydrogen bonding, and favorable cell-polymer interactions, making AA-PEAs appealing for biomedical applications, notably tissue engineering. However, addressing complex tissue regeneration requires additional enhancements. Introducing biologically instructive factors, like growth factors and peptides, becomes essential to facilitate cell growth, proliferation, and differentiation.
This study explores α-amino acid based functionalized polyester amides (AA-FPEAs) for their potential in tissue engineering, focusing on their underexplored role as thermoplastic resources for fused deposition modeling (FDM). Novel AA-FPEAs with alkyne moieties were synthesized and additively manufactured via FDM, highlighting their structure–property correlation. Employing a facile copper-free click chemistry strategy, we successfully attached a CGRGDS mimicking peptide to AA-FPEAs using UV light and a photoinitiator with water as a solvent. UV–Vis analysis confirmed the feasibility of the click reaction, and TOF-SIMS analysis verified CGRGDS attachment on AA-FPEA films and AM scaffolds. In vitro evaluation further demonstrated that AA-FPEAs support cell growth and proliferation, highlighting their biocompatibility. These findings underscore the potential of AA-FPEAs as versatile functionalized biomaterials for tissue engineering applications.
期刊介绍:
European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas:
Polymer synthesis and functionalization
• Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers.
Stimuli-responsive polymers
• Including shape memory and self-healing polymers.
Supramolecular polymers and self-assembly
• Molecular recognition and higher order polymer structures.
Renewable and sustainable polymers
• Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites.
Polymers at interfaces and surfaces
• Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications.
Biomedical applications and nanomedicine
• Polymers for regenerative medicine, drug delivery molecular release and gene therapy
The scope of European Polymer Journal no longer includes Polymer Physics.