Recent advances in bio-based production of organic acids by genetically engineered yeasts

IF 3.7 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biochemical Engineering Journal Pub Date : 2024-11-21 DOI:10.1016/j.bej.2024.109587

Ning Xu , Haiyan Gao , Yanran Wang , Chenxuan Liu , Lei Hu , Aiyong He , Wankui Jiang , Fengxue Xin

引用次数: 0

Abstract

In order to achieve the sustainable development of society and reduce environmental footprint of chemical industry, some cleaner and greener production methods are still needed. Microbial fermentation has shown great potentials for sustainable production of chemicals, which can convert renewable resources into different products under mild conditions. Particularly, organic acids production has become a highly competitive and rapidly developed field, as they show broad applications in food, cosmetic and medical areas. Especially, yeasts have shown many advantages in organic acids production especially at high osmotic pressure or low pH. Accordingly, this review will discuss the latest progress of engineered yeasts as cell factories for organic acids production. Different strategies for improvement of organic acids production will be introduced, and future perspectives will also be proposed.

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利用基因工程酵母生产有机酸的研究进展

为了实现社会的可持续发展，减少化学工业的环境足迹，还需要一些更清洁、更绿色的生产方法。微生物发酵可以在温和的条件下将可再生资源转化为不同的产品，在可持续生产化学品方面显示出巨大的潜力。特别是有机酸生产，在食品、化妆品和医疗等领域有着广泛的应用，已成为一个竞争激烈、发展迅速的领域。特别是在高渗透压或低ph条件下，酵母在生产有机酸方面显示出许多优势。本文将对工程酵母作为生产有机酸的细胞工厂的最新进展进行综述。介绍了改进有机酸生产的不同策略，并提出了未来的展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemical Engineering Journal 工程技术-工程：化工

CiteScore

7.10

自引率

5.10%

发文量

380

审稿时长

34 days

期刊介绍： The Biochemical Engineering Journal aims to promote progress in the crucial chemical engineering aspects of the development of biological processes associated with everything from raw materials preparation to product recovery relevant to industries as diverse as medical/healthcare, industrial biotechnology, and environmental biotechnology. The Journal welcomes full length original research papers, short communications, and review papers* in the following research fields: Biocatalysis (enzyme or microbial) and biotransformations, including immobilized biocatalyst preparation and kinetics Biosensors and Biodevices including biofabrication and novel fuel cell development Bioseparations including scale-up and protein refolding/renaturation Environmental Bioengineering including bioconversion, bioremediation, and microbial fuel cells Bioreactor Systems including characterization, optimization and scale-up Bioresources and Biorefinery Engineering including biomass conversion, biofuels, bioenergy, and optimization Industrial Biotechnology including specialty chemicals, platform chemicals and neutraceuticals Biomaterials and Tissue Engineering including bioartificial organs, cell encapsulation, and controlled release Cell Culture Engineering (plant, animal or insect cells) including viral vectors, monoclonal antibodies, recombinant proteins, vaccines, and secondary metabolites Cell Therapies and Stem Cells including pluripotent, mesenchymal and hematopoietic stem cells; immunotherapies; tissue-specific differentiation; and cryopreservation Metabolic Engineering, Systems and Synthetic Biology including OMICS, bioinformatics, in silico biology, and metabolic flux analysis Protein Engineering including enzyme engineering and directed evolution.