Genetic diversity of Brucella abortus strains from cattle and water buffalo in the Italian province of Caserta

IF 2.4 2区农林科学 Q3 MICROBIOLOGY

Veterinary microbiology Pub Date : 2024-12-01 DOI:10.1016/j.vetmic.2024.110314

Luigi Orrù , Antonella Lamontanara , Celestina Mascolo , Giorgia Borriello , Rubina Paradiso , Anna Cerrone , Paolo Coppa , Manuela Tittarelli , Carlo Ferrara , Esterina De Carlo , Giorgio Galiero , Alessandra Martucciello

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引用次数: 0

Abstract

Brucella abortus is an important zoonotic pathogen that infects cattle and buffaloes. In Italy the application of eradication programs combined with vaccination has greatly contributed to reduce the incidence of brucellosis. However, despite the eradication programs brucellosis continue to persist with a high endemicity in some areas of Italy including the province of Caserta. In the present study the genomes of 44 B. abortus strains isolated from different outbreak cases that affected the province of Caserta were sequenced to characterize the genetic diversity of the Brucella strains circulating during the period from 2017 to 2022. The relatedness among these isolates was compared to 52 publicly available genomes of Italian B. abortus isolates. The results highlighted a low genetic diversity in the B. abortus population present in the Caserta area with the persistence of a low number of Brucella lineages and suggests a reduction in circulating lineages in recent years due to eradication programs.

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意大利卡塞塔省牛和水牛产布鲁氏菌菌株的遗传多样性

流产布鲁氏菌是一种重要的感染牛、水牛的人畜共患病原体。在意大利，根除计划与疫苗接种相结合的应用大大有助于减少布鲁氏菌病的发病率。然而，尽管实施了根除计划，布鲁氏菌病在意大利的一些地区，包括卡塞塔省，仍然保持着很高的流行率。本研究对从卡塞塔省不同暴发病例中分离的44株流产布鲁氏菌进行了基因组测序，以表征2017年至2022年流行的布鲁氏菌菌株的遗传多样性。将这些分离株的亲缘性与52个公开获得的意大利abortus分离株基因组进行比较。结果强调了在Caserta地区存在的B. abortus种群的低遗传多样性，以及持续存在的低数量的布鲁氏菌谱系，并表明近年来由于根除计划而减少了循环谱系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary microbiology 农林科学-兽医学

CiteScore

5.90

自引率

6.10%

发文量

221

审稿时长

52 days

期刊介绍： Veterinary Microbiology is concerned with microbial (bacterial, fungal, viral) diseases of domesticated vertebrate animals (livestock, companion animals, fur-bearing animals, game, poultry, fish) that supply food, other useful products or companionship. In addition, Microbial diseases of wild animals living in captivity, or as members of the feral fauna will also be considered if the infections are of interest because of their interrelation with humans (zoonoses) and/or domestic animals. Studies of antimicrobial resistance are also included, provided that the results represent a substantial advance in knowledge. Authors are strongly encouraged to read - prior to submission - the Editorials (''Scope or cope'' and ''Scope or cope II'') published previously in the journal. The Editors reserve the right to suggest submission to another journal for those papers which they feel would be more appropriate for consideration by that journal. Original research papers of high quality and novelty on aspects of control, host response, molecular biology, pathogenesis, prevention, and treatment of microbial diseases of animals are published. Papers dealing primarily with immunology, epidemiology, molecular biology and antiviral or microbial agents will only be considered if they demonstrate a clear impact on a disease. Papers focusing solely on diagnostic techniques (such as another PCR protocol or ELISA) will not be published - focus should be on a microorganism and not on a particular technique. Papers only reporting microbial sequences, transcriptomics data, or proteomics data will not be considered unless the results represent a substantial advance in knowledge. Drug trial papers will be considered if they have general application or significance. Papers on the identification of microorganisms will also be considered, but detailed taxonomic studies do not fall within the scope of the journal. Case reports will not be published, unless they have general application or contain novel aspects. Papers of geographically limited interest, which repeat what had been established elsewhere will not be considered. The readership of the journal is global.