Ocular and palpebral manifestations of mastocytosis: A prospective single-center study

IF 3.1 4区医学 Q2 DERMATOLOGY

Annales De Dermatologie Et De Venereologie Pub Date : 2024-11-28 DOI:10.1016/j.annder.2024.103328

C. Guerin , E. Frouin , S. Doan , S. Charreau , C. Alleyrat , G. Tardieu , R. Flausse , M. Masson Regnault

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引用次数: 0

Abstract

Background

Ocular discomfort has been described as a frequent symptom in patients with mastocytosis, a rare disease resulting from accumulation of mast cells in organs.

Objectives

This study aims to assess the frequency and describe the nature of ocular and palpebral abnormalities in mastocytosis patients.

Patients and methods

We conducted a prospective, single-center study in adult mastocytosis patients, who were systematically examined by a dermatologist and an ophthalmologist with determination of tear cytokine levels.

Results

Twenty-one patients with a mean age of 60.7 ± 16.4 years were included. Nine patients presented with isolated cutaneous mastocytosis and 12 with indolent systemic mastocytosis. Seventeen patients (81.0%) presented with one or more eye symptoms. The most frequently reported symptoms were ocular itching (n = 12), dryness (n = 12), and excessive tearing (n = 9). Based on their Ocular Surface Disease Index scores, 11 patients (52.4%) were classified as having moderate or severe ocular surface disease. Eye examination revealed dry eye disease in 11 patients (52.4%), associated with superficial punctate keratitis in two patients and posterior blepharitis in 10 patients (47.6%). Tear cytokine levels of interleukin (IL)-1RA and IL-6 were not significantly different in mastocytosis patients compared to controls and did not vary according to ocular symptoms.

Conclusion

Dry eye disease and blepharitis were frequently found in this cohort of mastocytosis patients. Ocular consultation may be considered in this population to initiate eye hydration measures.

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来源期刊

Annales De Dermatologie Et De Venereologie 医学-皮肤病学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Les Annales de dermatologie sont le rendez-vous mensuel incontournable de toute la dermatologie francophone, grâce à leur comité de rédaction qui assure une sélection rigoureuse des articles selon les normes de l''édition scientifique internationale. Une revue didactique, véritable aide à la pratique médicale quotidienne Pour compléter et enrichir la partie scientifique, la rubrique Formation médicale continue propose aux lecteurs des textes didactiques et interactifs (Cas pour diagnostic, Notes de pharmacovigilance, la Question du praticien, Dermatologie chirurgicale, la Sélection bibliographique du mois...) qui les font bénéficier d''une formation post-universitaire diversifiée et de qualité. La revue consacre également un espace pour la publication de questions des lecteurs auxquelles des experts apportent une réponse.