Synthesis and analysis of antioxidant properties of gallate based bio-MOF for drug delivery application

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications Pub Date : 2024-11-21 DOI:10.1016/j.inoche.2024.113590

Manu Sharma , Pawan Kumar

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Abstract

A porous copper gallate bioinspired metal–organic framework (CuGA bio-MOF) has been synthesized using Copper (ll) chloride dihydrate and gallic acid (a polyphenol) under specific experimental environments to evaluate its antioxidant, drug tagging and release features. Initially, synthesized CuGA Bio-MOF has been analysed through various spectroscopic and microscopic techniques. To proceed further in research and gain a better understanding of readers, we have divided research work into two primary objectives: (a) evaluating the antioxidant properties of CuGA bio-MOF using the 2,2-diphenylpicrylhydrazyl (DPPH) assay and (b) exploring the release of the model drug Ibuprofen (IBU) from CuGA bio-MOF in phosphate-buffered saline (PBS). On confirmation of eminent antioxidant property (79.4 %) of pristine CuGA Bio-MOF, the tagging of Ibuprofen (IBU) on Bio-MOF, i.e., IBU@ CuGA Bio-MOF, has been confirmed through intermolecular hydrogen bonding. Our prolonged release of IBU studies endorsed 90 % release of the drug in 150 min at 37 °C, pH 7.4 in phosphate buffer saline (PBS) from IBU@ CuGA bio-MOF. Overall, the antioxidant features of CuGA bio-MOF and the drug release profile of IBU@CuGA bio-MOF exhibited potential real-world application as a suitable drug carrier.

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没食子酸酯基生物mof的合成及抗氧化性能分析

以二水合氯化铜（ll）和没食子酸（一种多酚）为原料，在特定的实验环境下合成了多孔没食子酸铜仿生金属-有机骨架（CuGA bio-MOF），并对其抗氧化、药物标记和释放特性进行了评价。首先，通过各种光谱和显微技术对合成的CuGA Bio-MOF进行了分析。为了进一步开展研究并更好地了解读者，我们将研究工作分为两个主要目标：(a)使用2,2-二苯基picrylhydrazyl （DPPH）法评估CuGA bio-MOF的抗氧化性能；(b)探索CuGA bio-MOF在磷酸盐缓冲盐水（PBS）中释放模型药物Ibuprofen （IBU）。在证实原始CuGA Bio-MOF具有优异的抗氧化性能（79.4%）的基础上，通过分子间氢键确定了Ibuprofen （IBU）在Bio-MOF上的标记，即IBU@ CuGA Bio-MOF。我们的延长释放研究表明，IBU@ CuGA bio-MOF在37°C、pH 7.4的磷酸盐缓冲盐水（PBS）中，在150分钟内释放90%的药物。综上所述，CuGA生物mof的抗氧化特性和IBU@CuGA生物mof的药物释放特性显示出作为一种合适的药物载体的潜在现实应用。

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来源期刊

Inorganic Chemistry Communications 化学-无机化学与核化学

CiteScore

5.50

自引率

7.90%

发文量

1013

审稿时长

53 days

期刊介绍： Launched in January 1998, Inorganic Chemistry Communications is an international journal dedicated to the rapid publication of short communications in the major areas of inorganic, organometallic and supramolecular chemistry. Topics include synthetic and reaction chemistry, kinetics and mechanisms of reactions, bioinorganic chemistry, photochemistry and the use of metal and organometallic compounds in stoichiometric and catalytic synthesis or organic compounds.