Microenvironment-responsive injectable hydrogel for neuro-vascularized bone regeneration

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2024-12-01 DOI:10.1016/j.mtbio.2024.101369

Wanshun Wang , Hu Chen , Jiacong Xiao , Dan Luo , Yonghui Hou , Jiheng Zhan , Yu Hou , Xing Li , Huili Yang , Shudong Chen , Dingkun Lin

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Abstract

Bone is a richly innervated and vascularized tissue, whereas nerve-vascular network reconstruction was often ignored in biomaterial design, resulting in delayed or incomplete bone healing. Inspired by the bone injury microenvironments, here we report a controllable drug delivery strategy using a pH and reactive oxygen species (ROS) dual-response injectable hydrogel. Based on the dynamic borate ester bond covalent crosslinking, nano-hydroxyapatite (HA) and curculigoside (CCG) are integrated into PVA/TSPBA (PT) to construct a responsive injectable hydrogel (PTHC), which scavenges excessive ROS from the injury microenvironment and responsively releases HA and CCG, providing favorable homeostasis and in situ sustained release drug delivery system for bone repair. Additionally, PTHC hydrogel can alleviate ROS-mediated intracellular oxidative and exhibit multiple biological activities of angiogenesis, neurogenesis, and osteogenesis. Furthermore, it reconstructs the microvascular network, accelerates sensory nerve repair, secretes neurotransmitters and bioactive factors, and improves neuro-vascularized bone regeneration. This multi-bioactive injectable hydrogel system offers a promising advance in therapeutic materials for bone repair.

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微环境反应性可注射水凝胶用于神经血管骨再生

骨是一种神经丰富且血管化的组织，然而神经血管网络的重建在生物材料设计中经常被忽视，导致骨愈合延迟或不完全。受骨损伤微环境的启发，我们在这里报告了一种使用pH和活性氧（ROS）双反应可注射水凝胶的可控药物递送策略。基于动态硼酸酯键共价交联，将纳米羟基磷灰石（HA）和curculigoside （CCG）整合到PVA/TSPBA （PT）中，构建响应性可注射水凝胶（PTHC），清除损伤微环境中过量的ROS，并响应性释放HA和CCG，为骨修复提供良好的稳态和原位缓释给药系统。此外，PTHC水凝胶可以减轻ros介导的细胞内氧化，并表现出血管生成、神经生成和成骨等多种生物活性。重建微血管网络，加速感觉神经修复，分泌神经递质和生物活性因子，促进神经血管化骨再生。这种具有多种生物活性的可注射水凝胶系统为骨修复治疗材料提供了一个有希望的进展。

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).