Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement

IF 27.4 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Ying Cai, Tiantian Xu, Binyu Zhu, Junfan Chen, Linyang Jiang, Xiaoting Shan, Rong Rong, Yao Li, Yang Yu, Xin Gao, Helen He Zhu, Lu Zhang, Pengcheng Zhang, Yaping Li
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Abstract

Filamentous structures exert biological functions mediated by multivalent interactions with their counterparts in sharp contrast with spherical ones. The physicochemical properties and unique behaviors of nanofilaments that are associated with multivalent interaction with protein are poorly understood. Here, peptide-based nanofilaments containing different homotetrapeptidic inserts are reported and their protein adsorption and biological fates are tested. By altering the homotetrapeptides, different peptidic conformations are imposed within the nanofilaments, which result in notable differences in the density of the intermolecular hydrogen bond, determining the amount of adsorbed proteins. The adsorbed proteins can further induce interfilament entanglement of different degrees and patterns, which influences biodistribution and phagocytosis. The nanofilaments with tetrahydroxyproline segment exhibit diminish interfilament entanglement, phagocytosis, and improve circulation, biodistribution, and antitumor efficacy. These findings can deepen the understanding of nanofilament-protein interactions and filament-filament interactions as in the case of amyloid-β plaque, and facilitate the rational design of nanofilaments through peptide conformation control for chemical engineering and anticancer drug delivery.

Abstract Image

构象通过调节蛋白质吸附和丝间缠结影响肽基纳米丝的生物学命运
与球形结构形成鲜明对比的是,丝状结构通过与其对应物的多价相互作用来发挥生物学功能。纳米丝与蛋白质的多价相互作用的物理化学性质和独特行为尚不清楚。本文报道了含有不同同四肽插入物的肽基纳米丝,并测试了它们的蛋白质吸附和生物命运。通过改变同四肽,不同的肽构象在纳米丝内被施加,这导致分子间氢键密度的显着差异,决定了吸附蛋白质的量。被吸附的蛋白质进一步诱导不同程度和模式的丝间缠结,从而影响生物分布和吞噬作用。含有四羟脯氨酸片段的纳米丝具有减少丝间缠结、减少吞噬、改善循环、生物分布和抗肿瘤功效的特点。这些发现可以加深对淀粉样蛋白-β斑块中纳米丝-蛋白相互作用和丝-丝相互作用的理解,并有助于通过肽构象控制来合理设计纳米丝,用于化学工程和抗癌药物的传递。
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来源期刊
Advanced Materials
Advanced Materials 工程技术-材料科学:综合
CiteScore
43.00
自引率
4.10%
发文量
2182
审稿时长
2 months
期刊介绍: Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.
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