Indocyanine green clearance's association with liver function in paediatric liver disease.

IF 2.4 4区医学 Q1 PEDIATRICS

Acta Paediatrica Pub Date : 2024-11-27 DOI:10.1111/apa.17518

G Ficerai-Garland, T W Helt, J Nielsen, R de Nijs, N H Vissing, C L Winther, S Møller, V Setterberg, J E Squires, L Borgwardt, V B Christensen

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引用次数: 0

Abstract

Aim: Indocyanine green (ICG) clearance, a sensitive biomarker for liver function, has not been validated in children. We assessed the association between ICG clearance and liver function in children with liver disease.

Methods: ICG plasma disappearance rate (ICG-PDR, %/min) was measured in children with liver disease. Mixed linear regression was used to assess the relationship between ICG-PDR and liver function tests (international normalised ratio, INR; prothrombin-proconvertin clotting time, PP).

Results: We included 124 patients with 183 visits. Of the visits, 60.1% were female, 85% had chronic liver disease and 42.5% were liver transplanted. The most common diseases in those without transplantation were autoimmune disease (18.6%) and biliary atresia (10.9%). Median ICG-PDR was 23.9%/min (interquartile range 15; 30.3). Mixed linear regression showed ICG-PDR was associated with INR (β = -0.006, 95% CI [-0.010, -0.003]) and PP (β = 0.005, 95% CI [0.003, 0.008]). However, only five visits were with patients who had acute liver failure (INR ≥2.0).

Conclusion: ICG clearance is associated with standard measures of liver function in children. ICG may aid decision-making in paediatric liver disease together with other biochemical measures, imaging and clinical presentation. However, further studies are needed to assess the usefulness of ICG in paediatric patients with INR >1.4.

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吲哚菁绿清除率与儿科肝病患者肝功能的关系。

目的：吲哚菁绿（ICG）清除率是一种敏感的肝功能生物标志物，但尚未在儿童中得到验证。我们评估了肝病儿童 ICG 清除率与肝功能之间的关联：方法：测量肝病患儿的 ICG 血浆消失率（ICG-PDR，%/分钟）。采用混合线性回归评估 ICG-PDR 与肝功能检测（国际标准化比值 INR；凝血酶原-转化酶凝血时间 PP）之间的关系：我们共纳入了 124 名患者，183 次就诊。其中，60.1%为女性，85%患有慢性肝病，42.5%进行过肝移植。在未接受移植的患者中，最常见的疾病是自身免疫性疾病（18.6%）和胆道闭锁（10.9%）。ICG-PDR 中位数为 23.9%/分钟（四分位距为 15；30.3）。混合线性回归显示，ICG-PDR 与 INR（β = -0.006，95% CI [-0.010，-0.003]）和 PP（β = 0.005，95% CI [0.003，0.008]）相关。结论：ICG清除率与标准测量指标相关：结论：ICG清除率与儿童肝功能的标准指标相关。ICG可与其他生化指标、影像学检查和临床表现一起辅助儿科肝病的决策。然而，还需要进一步的研究来评估 ICG 在 INR >1.4 的儿童患者中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries