Effects of Different Low-Intensity Pulsed Ultrasound Intensities and Durations on a Post-Traumatic Knee Joint Contracture Model in Rats

IF 2.4 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2025-02-01 DOI:10.1016/j.ultrasmedbio.2024.11.012

Ryo Nakahara , Akira Ito , Momoko Nagai-Tanima , Chia Tai , Zixi Zhao , Shixuan Xu , Fumika Miyamoto , Sachiko Abiko , Tomoki Aoyama , Hiroshi Kuroki

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引用次数: 0

Abstract

Objective

This study aimed to investigate the low-intensity pulsed ultrasound (LIPUS) therapeutic effects on knee joint dysfunction after immobilization following trauma and to identify the optimum LIPUS intensity and duration.

Methods

A knee post-traumatic joint contracture (PTJC) model was established in male Wistar rats divided into three groups: front irradiation (n = 4), medial irradiation (n = 3), and sham (n = 3). LIPUS irradiation was performed for 20 min/day (30 mW/cm² [spatial average temporal average] SATA, 1 MHz, duty cycle of 20%, 5 times/week, for 2 weeks). PTJC model rats were also divided into LIPUS and sham groups with LIPUS performed at different intensities (30 or 120 mW/cm² SATA) and durations (5 or 20 min). The range of motion (ROM) of the knee joint with skin and muscles (knee ROM) and without (knee joint intrinsic ROM) and the length of the posterior joint capsule and the intra-articular adhesion of the knee joint were evaluated.

Results

Knee ROM and knee joint intrinsic ROM were significantly larger in the front LIPUS group (p < 0.01). The length of the posterior capsule was significantly higher in the LIPUS groups (p < 0.01), but no significant differences between the LIPUS groups were observed. The intra-articular adhesion length was significantly lower in the 120 mW/cm²–20 min group than those in the 30 mW/cm²–5 min group (p < 0.01). The effects on LIPUS intensity and duration to intra-articular adhesion were not synergistic but additive.

Conclusion

LIPUS therapy may be a rehabilitation approach for preventing knee joint dysfunction after trauma or surgical invasion.

查看原文本刊更多论文

不同低强度脉冲超声波强度和持续时间对大鼠创伤后膝关节挛缩模型的影响

研究目的本研究旨在探讨低强度脉冲超声（LIPUS）对创伤后固定后膝关节功能障碍的治疗效果，并确定 LIPUS 的最佳强度和持续时间：方法：以雄性 Wistar 大鼠为对象，建立膝关节创伤后挛缩（PTJC）模型，分为三组：前部照射组（n = 4）、内侧照射组（n = 3）和假照射组（n = 3）。LIPUS 照射时间为 20 分钟/天（30 mW/cm2 [空间平均时间平均] SATA，1 MHz，占空比为 20%，5 次/周，持续 2 周）。PTJC 模型大鼠也被分为 LIPUS 组和假LIPUS 组，LIPUS 的强度（30 或 120 mW/cm2 SATA）和持续时间（5 或 20 分钟）各不相同。评估了膝关节带皮肤和肌肉的运动范围（ROM）（膝关节ROM）和不带皮肤和肌肉的运动范围（膝关节固有ROM），以及膝关节后关节囊的长度和关节内粘连情况：结果：前方 LIPUS 组的膝关节 ROM 和膝关节固有 ROM 明显更大（P < 0.01）。LIPUS组的后关节囊长度明显较高（P < 0.01），但LIPUS组之间无明显差异。120 mW/cm2-20 分钟组的关节内粘连长度明显低于 30 mW/cm2-5 分钟组（p < 0.01）。LIPUS强度和持续时间对关节内粘连的影响不是协同作用，而是相加作用：结论：LIPUS疗法可能是预防外伤或手术后膝关节功能障碍的一种康复方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.