Substance Use Disorder Among Patients with Primary Mental Illnesses in Southwestern Uganda.

IF 1.5 4区医学 Q3 PSYCHIATRY

Journal of Dual Diagnosis Pub Date : 2024-11-28 DOI:10.1080/15504263.2024.2434740

Abel Rubega, Moses Muwanguzi, Rahel Nkola, Alain Favina, Joseph Kirabira, Samuel Maling, Scholastic Ashaba

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Abstract

Objective: Substance use is common among people with primary mental illness especially schizophrenia and bipolar disorder compared to the general population and complicates treatment outcomes. Methods: We enrolled 385 patients with primary mental illnesses in southwestern Uganda between June and August 2022. We collected information on alcohol and cannabis use, social support, religiosity, adherence to treatment and sociodemographic characteristics. We run a logistic regression model to determine the factors associated with substance use disorder. Results: At multivariable analysis, being male (AOR = 13.61, 95% CI [3.66-50.63]: p <.001) and prior history of cannabis/alcohol use (AOR = 34.95, 95% CI [8.80-138.72]: p < .001) were significantly associated with substance use disorder while adherence to treatment was against substance use disorder (AOR = 0.27, 95% CI [0.09-0.83]: p = .03). Conclusions: Adherence to treatment is protective against substance use disorder among people with mental illness. Interventions aiming at preventing substance use disorder among people with mental illness should aim at promoting adherence to treatment.

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乌干达西南部原发性精神疾病患者的药物使用障碍。

目的：与普通人群相比，药物滥用在原发性精神疾病患者（尤其是精神分裂症和躁郁症患者）中很常见，并使治疗效果变得复杂。研究方法我们于 2022 年 6 月至 8 月间在乌干达西南部招募了 385 名原发性精神病患者。我们收集了有关酒精和大麻使用、社会支持、宗教信仰、坚持治疗和社会人口特征的信息。我们采用逻辑回归模型来确定与药物使用障碍相关的因素。结果如下在多变量分析中，男性（AOR = 13.61，95% CI [3.66-50.63]：P .001）和既往大麻/酒精使用史（AOR = 34.95，95% CI [8.80-138.72]：P .001）与药物使用障碍显著相关，而坚持治疗与药物使用障碍相对（AOR = 0.27，95% CI [0.09-0.83]：P = .03）。结论坚持治疗可以防止精神疾病患者出现药物使用障碍。旨在预防精神疾病患者药物使用障碍的干预措施应以促进坚持治疗为目标。

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来源期刊

Journal of Dual Diagnosis Multiple-

CiteScore

4.90

自引率

13.60%

发文量

期刊介绍： Journal of Dual Diagnosis is a quarterly, international publication that focuses on the full spectrum of complexities regarding dual diagnosis. The co-occurrence of mental health and substance use disorders, or “dual diagnosis,” is one of the quintessential issues in behavioral health. Why do such high rates of co-occurrence exist? What does it tell us about risk profiles? How do these linked disorders affect people, their families, and the communities in which they live? What are the natural paths to recovery? What specific treatments are most helpful and how can new ones be developed? How can we enhance the implementation of evidence-based practices at clinical, administrative, and policy levels? How can we help clients to learn active recovery skills and adopt needed supports, clinicians to master new interventions, programs to implement effective services, and communities to foster healthy adjustment? The Journal addresses each of these perplexing challenges.