[Application value of NRS-2002 combined with L3-SMI in the prognosis of patients with hepatitis B-related acute-on-chronic liver failure].

Q3 Medicine
Y W Zhao, Q L Chen, Q Zhan, J Li, Z H Huang, C L Zhu
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引用次数: 0

Abstract

Objective: To explore the predictive value of nutrition risk screening score 2002 (NRS-2002) and L3 skeletal muscle index (L3-SMI) for mortality within 90 days in patients with hepatitis B-related acute-on-chronic liver failure (HBV-ACLF). Methods: A retrospective analysis was conducted on 162 cases with HBV-ACLF who were diagnosed and treated at the First Affiliated Hospital of Nanjing Medical University from January 2017 to December 2023. Patients were divided into a survival and death group according to the 90-day survival status following diagnosis, and the clinical data between the two groups were compared. Binary logistic regression analysis was used to screen out the influencing factors related to the occurrence of mortality events. The receiver operating characteristic (ROC) curve was plotted to compare the predictive value of NRS-2002 and L3-SMI for mortality within 90 days in patients with HBV-ACLF. Results: There were statistically significant differences in lymphocyte count (LY), platelet (PLT), total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, international normalized ratio (INR), total bilirubin (TBil), urea, model for end-stage liver disease (MELD) score, NRS-2002 score, and L3-SMI between the death and the survival group (P<0.05). Multivariate analysis showed that higher levels of INR [odds ratio (OR)=4.412, 95% confidence interval (CI): 1.974-9.959, P<0.001], TBil (OR=1.004, 95%CI: 1.001-1.007, P<0.05), MELD score (OR=1.148, 95%CI: 1.071-1.232, P<0.001), NRS-2002 score (OR=1.526, 95%CI: 1.194-1.950, P<0.05), and lower levels of LY (OR=0.351, 95%CI: 0.103-0.755, P<0.01), and L3-SMI (OR=0.902, 95%CI: 0.854-0.953, P<0.001) were independent risk factors for 90-day mortality in patients with HBV-ACLF. The ROC curve showed that AUCL3-SMI was 0.706 and AUCNRS-2002 was 0.712. Multivariate logistic analysis showed that the optimal cutoff point for the prediction of 90-day mortality was 0.5. The area under the ROC curve was 0.841 (95%CI: 0.763-0.926), which was significantly higher than the single application of the MELD, NRS-2002, and L3-SMI indicators. Conclusion: The 90-day mortality risk has a correlation with low L3-SMI and high NRS-2002 scores in patients with HBV-ACLF. The SNM model has a certain predictive value for mortality within 90 days in patients with HBV-ACLF.

[NRS-2002 结合 L3-SMI 在 HBV-ACLF 患者预后判断中的应用价值]。
目的探讨营养风险筛查 2002(NRS-2002)和 L3 骨骼肌指数(L3-SMI)在预测乙型肝炎相关急慢性肝衰竭(HBV-ACLF)患者 90 天死亡率方面的意义。研究方法对2017年1月至2023年12月期间在南京医科大学第一附属医院接受治疗的162例HBV-ACLF患者进行回顾性分析。根据患者确诊后90天内的生存状况,将其分为两组:生存组和死亡组。使用二元逻辑回归模型确定与死亡率相关的因素,并使用接收器操作特征曲线(ROC)评估NRS-2002和L3-SMI对HBV-ACLF患者90天死亡率的预测价值。结果两组患者的淋巴细胞计数(LY)、血小板(PLT)、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、国际正常化比值(INR)、总胆红素(TBil)、尿素、终末期肝病模型(MELD)、NRS-2002 和 L3-SMI 均有统计学差异(POR=4.412,95%CI:1.974-9.959,POR=1.004,95%CI:1.001-1.007,P=0.002),MELD评分更高(OR=1.148,95%CI:1.071-1.232,POR=1.526,95%CI:1.194-1.950,POR=0.351,95%CI:0.103-0.755,POR=0.902,95%CI:0.854-0.953,PCI:0.763-0.926),显著高于单独使用 MELD、NRS-2002 和 L3-SMI 时。结论:较低的 L3-SMI 和较高的 NRS-2002 与 HBV-ACLF 患者的 90 天死亡风险相关。SNM 模型对这些患者的 90 天死亡率具有预测价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
中华肝脏病杂志
中华肝脏病杂志 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
7574
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