Grace Hey, Phuong Deleyrolle, Abeer Dagra, Tuo Lin, Derek Li, Kaitlyn Melnick, Nina McGrew, Muhammad Abdul Baker Chowdhury, Shahd Mohamed, Michael Goutnik, Si Chen, Ashley Ghiaseddin, Maryam Rahman
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引用次数: 0
Abstract
Introduction: Opiate drugs are commonly prescribed for postoperative pain relief following craniotomy. The aim of this study was to assess opiate use in patients undergoing craniotomy for high-grade glioma and to identify risk factors contributing to prolonged opiate use.
Methods: A retrospective chart review was conducted on adult patients undergoing craniotomy for high-grade glioma between January 2016 and January 2020. Medical records were assessed for history of pain syndrome, and alcohol, nicotine, and other substance use. Opiate length of utilization and dose measured by morphine equivalent dose (MED) was collected. Statistical analyses were conducted using R Statistical Software (v4.1.2; R Core Team 2021).
Results: A total of 295 patients met inclusion criteria, with 26.4% undergoing biopsy and 73.6% undergoing craniotomy for resection. The average immediate postoperative MED/day was 20.3 (SD 21.5) and average duration of outpatient opiate use was 15.1 days (SD 63.1 days). Male sex and history of tobacco use were associated with increased MED/day in the postoperative period. A stratified analysis showed that, for patients undergoing craniotomy, MED/day was significantly increased with male sex and history of tobacco use. For patients undergoing biopsy, MED/day was significantly increased with history of other substance use. History of pain syndrome significantly increased the odds of opiate prescription renewal. Age significantly reduced the odds of opiate prescription renewal.
Conclusions: Postoperative opiate use in this cohort is modest. Increased opiate use is associated with comorbidities known to modulate pain perception. Prospective studies should be conducted to provide more robust data.
期刊介绍：
World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
The journal''s mission is to:
-To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care.
-To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide.
-To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients.
Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS
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