Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium.

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2024-11-29 Epub Date: 2024-11-27 DOI:10.1126/sciadv.adr2084

Siwen Wang, Emma Casey, Joanne Sordillo, Sofía Aguilar-Lacasaña, Fernanda Morales Berstein, Richard J Biedrzycki, Sonia Brescianini, Su Chen, Amy Hough, Elena Isaevska, Woo Jin Kim, Marion Lecorguillé, Sebastian Shaobo Li, Christian M Page, Jaehyun Park, Stefan Röder, Kristina Salontaji, Gillian Santorelli, Yidan Sun, Sungho Won, Eric Zillich, Lea Zillich, Isabella Annesi-Maesano, S Hasan Arshad, Mariona Bustamante, Charlotte A M Cecil, Hannah R Elliott, Susan Ewart, Janine F Felix, Luigi Gagliardi, Siri E Håberg, Gunda Herberth, Barbara Heude, John W Holloway, Anke Huels, Wilfried Karmaus, Gerard H Koppelman, Stephanie J London, Sunni L Mumford, Lorenza Nisticò, Maja Popovic, Franca Rusconi, Enrique F Schisterman, Dan J Stein, Tabea Send, Henning Tiemeier, Judith M Vonk, Martine Vrijheid, Joseph Leo Wiemels, Stephanie H Witt, John Wright, Edwina H Yeung, Heather J Zar, Ana C Zenclussen, Hongmei Zhang, Jorge E Chavarro, Marie-France Hivert

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引用次数: 0

Abstract

Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome-wide association studies to examine the associations between delivery mode and blood DNA methylation at birth and its persistence in early childhood. Participants were from 19 pregnancy cohorts (9833 term newborns) and 6 pediatric cohorts (2429 children aged 6 to 10 years). We identified six CpGs in cord blood associated with cesarean delivery (effect size range: 0.4 to 0.7%, P < 1.0 × 10^-7): MAP2K2 (cg19423175), LIM2 (cg01500140), CNP (cg13917614), BLM (cg18247172), RASA3 (cg22348356), and RUNX3 (cg20674490), independent of cell proportions and other confounders. In childhood, none of these CpGs were associated with cesarean delivery, and no additional CpGs were identified. Delivery mode was associated with cell proportions at birth but not in childhood. Further research is needed to elucidate cesarean delivery's molecular influence on offspring health.

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剖腹产与出生时和儿童期的血液 DNA 甲基化：妊娠与儿童表观遗传学联合会的元分析。

与经阴道分娩的婴儿相比，经剖宫产分娩的婴儿患代谢、免疫和神经发育疾病的风险更高，但其机制仍不清楚。我们对全表观基因组关联研究进行了荟萃分析，以研究分娩方式与出生时血液DNA甲基化之间的关联及其在幼儿期的持续性。研究对象来自 19 个孕期队列（9833 名足月儿）和 6 个儿科队列（2429 名 6-10 岁儿童）。我们在脐带血中发现了 6 个与剖宫产相关的 CpGs（效应大小范围：0.4% 至 0.7%，P < 1.0 × 10-7）：MAP2K2（cg19423175）、LIM2（cg01500140）、CNP（cg13917614）、BLM（cg18247172）、RASA3（cg22348356）和 RUNX3（cg20674490），与细胞比例和其他混杂因素无关。在儿童期，这些 CpGs 均与剖宫产无关，也未发现其他 CpGs。分娩方式与出生时的细胞比例有关，但与儿童期无关。要阐明剖宫产对后代健康的分子影响，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.