Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders.

IF 7.8 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Petra Zimmermann, Salome Kurth, Benoit Pugin, Nicholas A Bokulich
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引用次数: 0

Abstract

Melatonin (MT) (N-acetyl-5-methoxytryptamine) is an indoleamine recognized primarily for its crucial role in regulating sleep through circadian rhythm modulation in humans and animals. Beyond its association with the pineal gland, it is synthesized in various tissues, functioning as a hormone, tissue factor, autocoid, paracoid, and antioxidant, impacting multiple organ systems, including the gut-brain axis. However, the mechanisms of extra-pineal MT production and its role in microbiota-host interactions remain less understood. This review provides a comprehensive overview of MT, including its production, actions sites, metabolic pathways, and implications for human health. The gastrointestinal tract is highlighted as an additional source of MT, with an examination of its effects on the intestinal microbiota. This review explores whether the microbiota contributes to MT in the intestine, its relationship to food intake, and the implications for human health. Due to its impacts on the intestinal microbiota, MT may be a valuable therapeutic agent for various dysbiosis-associated conditions. Moreover, due to its influence on intestinal MT levels, the microbiota may be a possible therapeutic target for treating health disorders related to circadian rhythm dysregulation.

将人体肠道中的微生物褪黑激素代谢作为菌群失调和节律紊乱的治疗靶点。
褪黑素(MT)(N-乙酰-5-甲氧基色胺)是一种吲哚胺,主要作用是通过调节人类和动物的昼夜节律来调节睡眠。除了与松果体有关外,它还能在多种组织中合成,发挥激素、组织因子、自体类固醇、类旁分泌物和抗氧化剂的作用,影响多个器官系统,包括肠道-大脑轴。然而,人们对松果体外 MT 的产生机制及其在微生物群-宿主相互作用中的作用仍然知之甚少。本综述全面概述了 MT,包括其生产、作用部位、代谢途径以及对人体健康的影响。本综述强调胃肠道是 MT 的另一个来源,并探讨了 MT 对肠道微生物群的影响。本综述探讨了微生物群是否对肠道中的 MT 起作用、其与食物摄入的关系以及对人体健康的影响。由于 MT 对肠道微生物群的影响,它可能是治疗各种与菌群失调相关疾病的重要药物。此外,由于其对肠道 MT 水平的影响,微生物群可能成为治疗与昼夜节律失调有关的健康疾病的治疗目标。
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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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