Hakan Gem, Maryam Ebadi, Gale Sebastian, Rania Abasaeed, Michele Lloid, Samuel S Minot, David R Dean, Armin Rashidi
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引用次数: 0
Abstract
The success of allogeneic hematopoietic cell transplantation (alloHCT) in curing hematologic disorders is limited by its short- and long-term toxicities. One such toxicity is oral mucositis (OM), causing pain, speech/swallowing difficulty, and prolonged hospitalization. Although conditioning chemoradiotherapy is the direct cause of OM, potential host-intrinsic mediators of mucosal injury remain elusive. We hypothesized that the oral microbiota may influence OM severity. We used a validated comprehensive scoring system based on specialized Oral Medicine examinations to longitudinally quantify OM severity in alloHCT recipients. High-throughput multi-site profiling of the oral microbiota was performed in parallel. We identify a sex-dependent commensal bacterium, Oribacterium asaccharolyticum, whose presence in saliva before transplantation is associated with more severe OM 14 days after transplantation. The sex predilection of this species correlated with higher uric acid levels in men. Our findings represent the first sex-dependent microbiota-mediated pathway in OM pathogenesis and introduce novel targets for preventative interventions.
异基因造血细胞移植(alloHCT)在治疗血液病方面的成功受到其短期和长期毒性的限制。其中一种毒性是口腔粘膜炎(OM),会导致疼痛、语言/吞咽困难和长期住院。尽管条件性化放疗是导致口腔黏膜炎的直接原因,但黏膜损伤的潜在宿主内在介质仍然难以捉摸。我们假设口腔微生物群可能会影响 OM 的严重程度。我们使用基于专业口腔医学检查的有效综合评分系统对异体肝移植受者的 OM 严重程度进行纵向量化。同时进行了高通量多部位口腔微生物群分析。我们发现了一种性别依赖性共生细菌--Oribacterium asaccharolyticum,其在移植前存在于唾液中与移植后 14 天更严重的 OM 相关。这种细菌的性别偏好与男性尿酸水平较高有关。我们的研究结果首次提出了OM发病机制中性别依赖性微生物群介导的途径,并为预防性干预措施引入了新的目标。
期刊介绍:
npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.