Integrated metabolome and microbiome strategy reveals the therapeutic effect of nervonic acid on Alzheimer's disease rats

IF 4.8 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Nutritional Biochemistry Pub Date : 2024-11-26 DOI:10.1016/j.jnutbio.2024.109813

Ziyi Chen , Shu Liu , Fengrui Song , Zong Hou , Hui Zhou , Yuting Fan , Rongjin Wang , Zhongying Liu

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Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disease. Nervonic acid is a component of breast milk and is also found in fish oil and specific vegetable oils. Studies have shown that nervonic acid is essential for the development of the human nervous system. In this study, Morris water maze (MWM) test and pathological analysis showed that nervonic acid could improve cognitive deficits and brain nerve damage in AD rats. Then, through sequencing, we found that nervonic acid increased the abundance of beneficial bacteria such as Lactobacillus and Bacteroides, and decreased the abundance of Pseudomonadaceae_Pseudomonas. Not only that, nervonic acid also regulates the production of short-chain fatty acids (SCFA) and the levels of 29 fecal metabolites, and affects the metabolism of linoleic acid, α-linolenic acid, arachidonic acid, and sphingolipid. Finally, we verified the regulatory effect of nervonic acid on metabolic enzyme activity.

Abstract Image

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综合代谢组和微生物组策略揭示了神经酸对阿尔茨海默病大鼠的治疗效果。

阿尔茨海默病（AD）是一种复杂的神经退行性疾病。神经氨酸是母乳的一种成分，也存在于鱼油和特定的植物油中。研究表明，神经酸对人体神经系统的发育至关重要。在这项研究中，莫里斯水迷宫（MWM）试验和病理分析表明，神经酸能改善AD大鼠的认知障碍和脑神经损伤。然后，通过测序，我们发现神经酸能增加乳酸杆菌和乳杆菌等有益菌的数量，降低假单胞菌的数量。不仅如此，神经酸还能调节短链脂肪酸（SCFA）的产生和29种粪便代谢产物的水平，并影响亚油酸、α-亚麻酸、花生四烯酸和鞘脂的代谢。最后，我们验证了神经酸对代谢酶活性的调节作用。

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来源期刊

Journal of Nutritional Biochemistry 医学-生化与分子生物学

CiteScore

9.50

自引率

3.60%

发文量

237

审稿时长

68 days

期刊介绍： Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.