Fish: a new xenograft source for maxillary sinus lifting.

IF 2.2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Applied Oral Science Pub Date : 2024-11-22 eCollection Date: 2024-01-01 DOI:10.1590/1678-7757-2024-0245

Emrah Soylu, Musab Süleyman Kilavuz, Fatih Duman, Hasan Ekeer, Zeynep Burçin Gönen, Beyza Kahraman, Arzu Hanım Yay, Demet Bolat

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引用次数: 0

Abstract

Objective: Although autogenous grafting is accepted as the gold standard in intraoral grafting, xenogenous grafts are frequently used in sinus lift surgeries due to their osteoinductive and osteoconductive properties. This study aimed to investigate the efficacy of fish spine-derived xenogenic grafts in sinus augmentation surgery.

Material and methods: In this study, a fish spine-derived xenogenic graft was produced for comparison with autogenous graft and bovine derived xenogenic grafts. Twenty-one New Zealand rabbits were used. Autogenous grafts (AG- Group 1), as well as bovine-derived (bHAP - Group 2) and fish spine-derived (fHAP - Group 3) xenogenic grafts were placed in the right and left sinuses of rabbits. The animals were sacrificed at the 4th and 8th weeks. New bone formation (NBF) was evaluated through histological examination, while bone volume (BV), new bone surface/bone volume (BS-BV), new bone surface/tissue volume (BS-TV), and trabecular separation (Tb-Sp) were assessed via Micro-CT. Statistical significance was considered at p<0.05.

Results: Histological examination revealed a significant difference in NBF between AG-bHAP (p<0.001), as well as between fHAP-bHAP (p<0.001) in the fourth-week group. No significant difference was found in the eighth-week group (p=0.130). In the eighth-week group, a statistically significant difference was found between fHAP and bHAP in terms of BV. (p=0.007).

Conclusion: Although both graft materials used in this study showed positive effects on bone regeneration, fHAP and AG presented similar effects on bone regeneration and were superior to bHAP.

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鱼：上颌窦提升术的新异种移植来源。

目的：虽然自体移植物被认为是口腔内移植物的金标准，但异种移植物因其具有骨诱导和骨诱导特性而经常被用于上颌窦提升手术。本研究旨在探讨鱼刺来源的异种移植物在上颌窦增高手术中的疗效：本研究制作了一种鱼刺来源的异种移植物，与自体移植物和牛来源的异种移植物进行比较。研究使用了 21 只新西兰兔。将自体移植物（AG-第 1 组）、牛源性（bHAP-第 2 组）和鱼刺源性（fHAP-第 3 组）异种移植物分别植入兔子的左右鼻窦。动物在第 4 周和第 8 周被处死。新骨形成（NBF）通过组织学检查进行评估，而骨量（BV）、新骨面/骨量（BS-BV）、新骨面/组织量（BS-TV）和小梁分离（Tb-Sp）则通过 Micro-CT 进行评估。统计学意义以 pResults 为标准：组织学检查显示，AG-bHAP 与 NBF 之间存在显著差异（p 结论：虽然本研究中使用的两种移植物材料对骨再生都有积极作用，但 fHAP 和 AG 对骨再生的作用相似，且优于 bHAP。

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来源期刊

Journal of Applied Oral Science 医学-牙科与口腔外科

CiteScore

4.80

自引率

3.70%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal of Applied Oral Science is committed in publishing the scientific and technologic advances achieved by the dental community, according to the quality indicators and peer reviewed material, with the objective of assuring its acceptability at the local, regional, national and international levels. The primary goal of The Journal of Applied Oral Science is to publish the outcomes of original investigations as well as invited case reports and invited reviews in the field of Dentistry and related areas.