Patients with relapsing-remitting multiple sclerosis show accelerated whole brain volume and thalamic volume loss early in disease.

IF 2.4 3区医学 Q2 CLINICAL NEUROLOGY

Neuroradiology Pub Date : 2024-11-28 DOI:10.1007/s00234-024-03516-7

Roland Opfer, Matthias Schwab, Sabine Bangoura, Mousumi Biswas, Julia Krüger, Lothar Spies, Carola Gocke, Christian Gaser, Sven Schippling, Hagen H Kitzler, Tjalf Ziemssen

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引用次数: 0

Abstract

Background: The aim of this study was to investigate the dynamics of annual whole brain volume loss (BVL/year) and annual thalamic volume loss (ThalaVL/year) in patients with relapsing-remitting multiple sclerosis (PwRRMS) during the course of the disease.

Methods: A longitudinal database of magnetic resonance imaging (MRI) scans of 195 healthy individuals (age range, 22.8-63.7 years) and longitudinal MRI data of 256 PwRRMS (age range, 20.1-60.8 years) were analyzed and compared. BVL/year and ThalaVL/year were computed for healthy individuals as well as for all patients with MS using a Jacobian integration approach. A linear regression was used to compute the relationship between age and BVL/year and ThalaVL/year for healthy individuals. The linear regression was then used to decompose the BVL/year and ThalaVL/year into a multiple sclerosis (MS)-related and an age-related component for each PwRRMS. PwRRMS were dichotomized into early-phase RRMS (disease duration ≤ 6 years) and later-phase RRMS (disease duration > 6 years), and a t-test was performed to test for differences between these groups.

Results: The 135 early-phase patients (disease duration, ≤ 6 years) had statistically significantly higher MS-related BVL/year than the later-phase patients (n = 121) (- 0.21% vs. - 0.06%, p = 0.007). For MS-related ThalaVL/year, the difference between the groups was even more pronounced (- 0.39% vs. - 0.00%, p < 0.0001).

Conclusions: Our results indicate that in PwRRMS, the MS-related components of BVL/year and ThalaVL/year are accelerated in early phases and slowdown in later phases of the disease. This might explain why early intervention often leads to improved outcomes in patients with MS.

查看原文本刊更多论文

复发-缓解型多发性硬化症患者在发病初期会出现全脑体积和丘脑体积加速缩小的现象。

研究背景本研究旨在探讨复发缓解型多发性硬化症（PwRRMS）患者在发病过程中每年全脑容积损失（BVL/年）和丘脑容积损失（ThalaVL/年）的动态变化：对195名健康人（年龄在22.8-63.7岁之间）的纵向磁共振成像（MRI）扫描数据库和256名复发性多发性硬化症患者（年龄在20.1-60.8岁之间）的纵向磁共振成像数据进行了分析和比较。采用雅各布积分法计算了健康人和所有多发性硬化症患者的 BVL/年和 ThalaVL/年。使用线性回归计算健康人的年龄与 BVL/年和 ThalaVL/年之间的关系。然后，利用线性回归将每个 PwRRMS 的 BVL/year 和 ThalaVL/year 分解为与多发性硬化症（MS）相关的部分和与年龄相关的部分。PwRRMS被分为早期RRMS（病程≤6年）和晚期RRMS（病程>6年），并进行t检验来检验这两组之间的差异：135名早期患者（病程≤6年）与MS相关的BVL/年明显高于晚期患者（n = 121）（- 0.21% vs. - 0.06%，p = 0.007）。至于 MS 相关的 ThalaVL/年，两组之间的差异更加明显（- 0.39% vs. - 0.00%，p 结论：我们的研究结果表明，PwRR 患者的 BVL/年与 MS 相关的 ThalaVL/年之间存在显著差异：我们的研究结果表明，在 PwRRMS 中，BVL/年和 ThalaVL/年中与 MS 相关的部分在疾病早期会加速，而在疾病晚期则会减慢。这或许可以解释为什么早期干预往往能改善多发性硬化症患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroradiology 医学-核医学

CiteScore

5.30

自引率

3.60%

发文量

214

审稿时长

4-8 weeks

期刊介绍： Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.