Hyalinizing clear cell carcinoma of the lung: a case report and literature review.

IF 2.4 3区医学 Q2 PATHOLOGY

Diagnostic Pathology Pub Date : 2024-11-28 DOI:10.1186/s13000-024-01579-x

Yu-Ju Su, Yun-Shao Wu, Cheng-Hung How, Min-Shu Hsieh

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引用次数: 0

Abstract

Background: Primary pulmonary hyalinizing clear cell carcinoma (HCCC) is an exceedingly rare tumor with unique clinicopathological features, posing major diagnostic challenges.

Case presentation: We present a case of a 74-year-old woman with a lung nodule incidentally detected in the right middle lobe (RML) through ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) imaging. Through comprehensive evaluations by thoracic surgeons, she underwent video-assisted thoracic surgery of RML lobectomy to excise the lung nodule. Subsequent histopathological and immunohistochemical analyses confirmed the nodule as HCCC. She was discharged without any postoperative complications. No recurrence has been observed after two years of follow-up. This case underscored the importance of comprehensive imaging modalities and pathological analysis in the management of primary pulmonary HCCC.

Conclusions: This report highlights the critical role of imaging techniques and pathological analysis in diagnosing primary pulmonary HCCC, with this case demonstrating the essential value of ¹⁸F-FDG PET/CT integration.

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肺透明细胞癌：病例报告和文献综述。

背景：原发性肺透明细胞癌（HCCC）是一种极为罕见的肿瘤，具有独特的临床病理特征，给诊断带来了巨大挑战：本病例是一名 74 岁女性的病例，她通过 18F- 氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）成像意外发现右肺中叶（RML）有一个肺结节。经过胸外科医生的综合评估，她接受了视频辅助胸腔手术的 RML 肺叶切除术，切除了肺部结节。随后的组织病理学和免疫组化分析证实该结节为 HCCC。她出院时未出现任何术后并发症。随访两年后未发现复发。该病例强调了综合成像模式和病理分析在原发性肺 HCCC 治疗中的重要性：本报告强调了成像技术和病理分析在诊断原发性肺部 HCCC 中的关键作用，本病例显示了 18F-FDG PET/CT 整合的重要价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Pathology 医学-病理学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).