Patients' Characteristics Associated With Size of Ruptured and Unruptured Intracranial Aneurysms

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2024-11-28 DOI:10.1002/brb3.70161

Thiemo Florin Dinger, Mehdi Chihi, Meltem Gümüs, Christoph Rieß, Alejandro Nicolas Santos, Mats Leif Moskopp, Jan Rodemerk, Maximilian Schüßler, Marvin Darkwah Oppong, Yan Li, Karsten Henning Wrede, Philipp René Dammann, Ulrich Sure, Ramazan Jabbarli

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引用次数: 0

Abstract

Objective

The size of unruptured intracranial aneurysms (UIA) remains the most crucial risk factor for treatment decisions. On the other side, there is a non-negligible portion of small ruptured IA and large stable UIA. This study aimed to identify the patients' characteristics related to IA size in the context of IA rupture status.

Methods

A total of 2152 patients, with 1002 being hospitalized for an acute aneurysmal subarachnoid hemorrhage (SAH), were included from our institutional IA database. Different demographic and clinical characteristics of patients and IA were collected. IA size was the study endpoint, assessed as continuous variable in univariate and multivariable linear regression analysis, separately for ruptured (R) IA and UIA.

Results

The mean IA size was 8.3 and 7.3 mm in the UIA and RIA subpopulations, respectively. Higher age (p = 0.003) and baseline blood urea level (p < 0.001) were independently associated with increasing UIA size. In contrast, location at the posterior circulation (p < 0.001), familiar intracranial aneurysms (p < 0.001), serum potassium (p = 0.006), and total serum protein (p = 0.019) were related to smaller UIA size in the multivariate analysis. For RIA, a statistically significant and independent association was detected for location (p = 0.019), history of gastrointestinal diseases (p = 0.042), and levothyroxine intake (p = 0.002).

Conclusions

Identification of clinical characteristics related to the size of ruptured and unruptured IA allows a more differentiated view on the genesis of RIA and UIA and the value of sack size as a basis for therapeutic decision-making. More research is needed to verify the identified risk factors.

Abstract Image

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与颅内动脉瘤破裂和未破裂大小相关的患者特征。

目的：未破裂颅内动脉瘤（UIA）的大小仍然是决定治疗的最关键风险因素。另一方面，小的破裂颅内动脉瘤和大的稳定颅内动脉瘤的比例也不容忽视。本研究的目的是在 IA 破裂状态的背景下，确定与 IA 大小相关的患者特征：方法：本机构的 IA 数据库共纳入 2152 例患者，其中 1002 例因急性动脉瘤性蛛网膜下腔出血（SAH）住院。研究人员收集了患者和IA的不同人口统计学特征和临床特征。IA大小是研究终点，在单变量和多变量线性回归分析中作为连续变量评估，分别针对破裂（R）IA和UIA：结果：UIA和RIA亚群的IA平均大小分别为8.3毫米和7.3毫米。年龄越大（P = 0.003），基线血尿素水平越高（P = 0.004），则尿酸水平越高（P = 0.005）：确定与破裂和未破裂内脏器官大小相关的临床特征，可使人们对 RIA 和 UIA 的成因以及囊袋大小作为治疗决策依据的价值有更明确的认识。需要进行更多的研究来验证已确定的风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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