Impact of alcohol use disorder on cognition in correlation with aging: a community-based retrospective cohort study.

IF 2.1 4区医学 Q3 SUBSTANCE ABUSE

Alcohol and alcoholism Pub Date : 2024-11-18 DOI:10.1093/alcalc/agae080

Hesham Essa, Hossam M Ali, Paul H Min, Dina N Ali, Val Lowe, Ronald C Petersen, David S Knopman, Emily S Lundt, Carly T Mester, Nicholas L Bormann, Doo-Sup Choi

{"title":"Impact of alcohol use disorder on cognition in correlation with aging: a community-based retrospective cohort study.","authors":"Hesham Essa, Hossam M Ali, Paul H Min, Dina N Ali, Val Lowe, Ronald C Petersen, David S Knopman, Emily S Lundt, Carly T Mester, Nicholas L Bormann, Doo-Sup Choi","doi":"10.1093/alcalc/agae080","DOIUrl":null,"url":null,"abstract":"Aims: Excessive alcohol use is associated with an increased risk of cognitive impairment. Since increased amyloid plaque burden exacerbates cognitive decline, we sought to assess the potential impact of alcohol use disorder (AUD) on cognition, memory, and amyloid burden corresponding with age.Methods: We conducted the retrospective analysis with 6036 subjects, including 269 AUD+ subjects. A four-item CAGE (C-Cutting Down, A-Annoyance by Criticism, G-Guilty Feeling, E-Eye-openers) alcohol questionnaire was given during the recruitment to determine AUD in each participant. We assessed cognitive function, focusing on memory using neuropsychological testing. For 1038 participants, including 57 AUD+ subjects, we measured amyloid burden using the 11C Pittsburgh Compound B tracer-based positron emission tomography imaging.Results: AUD+ was significantly associated with lower scores of cognition and memory function relative to AUD- individuals. No significant association was found with AUD and elevated brain amyloid under the age of 65. However, further analysis showed that those aged ≥65 showed greater odds for abnormal amyloid in AUD+ compared to AUD- participants.Conclusions: Our results underscore AUD as a risk factor for cognitive decline and diminished memory, particularly in aging populations. The role of AUD in brain amyloid accumulation requires further study.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601986/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcohol and alcoholism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/alcalc/agae080","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}

引用次数: 0

Abstract

Aims: Excessive alcohol use is associated with an increased risk of cognitive impairment. Since increased amyloid plaque burden exacerbates cognitive decline, we sought to assess the potential impact of alcohol use disorder (AUD) on cognition, memory, and amyloid burden corresponding with age.

Methods: We conducted the retrospective analysis with 6036 subjects, including 269 AUD+ subjects. A four-item CAGE (C-Cutting Down, A-Annoyance by Criticism, G-Guilty Feeling, E-Eye-openers) alcohol questionnaire was given during the recruitment to determine AUD in each participant. We assessed cognitive function, focusing on memory using neuropsychological testing. For 1038 participants, including 57 AUD+ subjects, we measured amyloid burden using the 11C Pittsburgh Compound B tracer-based positron emission tomography imaging.

Results: AUD+ was significantly associated with lower scores of cognition and memory function relative to AUD- individuals. No significant association was found with AUD and elevated brain amyloid under the age of 65. However, further analysis showed that those aged ≥65 showed greater odds for abnormal amyloid in AUD+ compared to AUD- participants.

Conclusions: Our results underscore AUD as a risk factor for cognitive decline and diminished memory, particularly in aging populations. The role of AUD in brain amyloid accumulation requires further study.

查看原文本刊更多论文

酒精使用障碍对认知能力的影响与衰老的相关性：一项基于社区的回顾性队列研究。

目的：过度饮酒会增加认知障碍的风险。由于淀粉样蛋白斑块负担的增加会加剧认知功能的衰退，因此我们试图评估饮酒障碍（AUD）对认知、记忆以及与年龄相应的淀粉样蛋白负担的潜在影响：我们对 6036 名受试者进行了回顾性分析，其中包括 269 名 AUD+ 受试者。在招募过程中，我们对每位受试者进行了四项CAGE（C-Cutting Down，A-Annoyance by Criticism，G-Guilty Feeling，E-Eye-openers）酒精问卷调查，以确定受试者是否患有AUD。我们通过神经心理学测试评估了认知功能，重点是记忆力。对于包括 57 名 AUD+ 受试者在内的 1038 名参与者，我们使用基于 11C 匹兹堡化合物 B 示踪剂的正电子发射断层扫描成像技术测量了淀粉样蛋白负荷：结果：与 AUD- 相比，AUD+ 与认知和记忆功能得分较低有明显关联。在 65 岁以下人群中，未发现 AUD 与脑淀粉样蛋白升高有明显关联。然而，进一步分析表明，与 AUD- 参与者相比，年龄≥65 岁的 AUD+ 参与者出现淀粉样蛋白异常的几率更高：我们的研究结果表明，AUD 是认知能力下降和记忆力减退的一个风险因素，尤其是在老年人群中。AUD在大脑淀粉样蛋白积累中的作用需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Alcohol and alcoholism 医学-药物滥用

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

4-8 weeks

期刊介绍： About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.