{"title":"Advances in metallic biomaterial-based osteomyelitis theranostics","authors":"Shichang Liu, Ming Yang, Xinfei Wang, Junyi Yin, Wen Hong, Xuxu Chen, Xinhua Yin","doi":"10.1007/s42114-024-01047-6","DOIUrl":null,"url":null,"abstract":"<div><p>The treatment of osteomyelitis, a common orthopedic infection, presents a significant challenge for clinicians. The conventional approach to treating osteomyelitis involves prolonged and high-dose antibiotic therapy along with multiple surgical debridements; however, it is plagued by inadequate therapeutic efficacy and frequent re-sensitization. Therefore, the development of biomaterials possessing localized healing and antibacterial properties is imperative. In recent years, metal-based biomaterials have emerged as a hot research topic in the management of osteomyelitis due to their inherent antibacterial and bactericidal characteristics. This article provides an overview of the benefits and applications of metal-based biomaterials in treating osteomyelitis, encompassing magnesium-based, iron-based, copper-based, and noble metal–based materials as well as other metallic biomaterials. Metal-based biomaterials exhibit remarkable potential for addressing osteomyelitis owing to their broad-spectrum antibacterial properties, biodegradability, and ability to promote the proliferation of osteoblasts. Furthermore, these materials are gradually being employed in various biomedical therapies such as sonodynamic therapy, microwave dynamic therapy, photodynamic therapy immunotherapy, and multimodal therapy for effective treatment while circumventing the limitations associated with traditional antibiotic approaches. Metal-based biomaterials hold promising prospects for managing osteomyelitis effectively. Further research should focus on exploring solutions pertaining to challenges related to drug resistance, responsible drug release, and impact on mechanical properties of matrices induced by drugs, to facilitate clinical application of metal-based biomaterials in treating osteomyelitis.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 1","pages":""},"PeriodicalIF":23.2000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Composites and Hybrid Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s42114-024-01047-6","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, COMPOSITES","Score":null,"Total":0}
引用次数: 0
Abstract
The treatment of osteomyelitis, a common orthopedic infection, presents a significant challenge for clinicians. The conventional approach to treating osteomyelitis involves prolonged and high-dose antibiotic therapy along with multiple surgical debridements; however, it is plagued by inadequate therapeutic efficacy and frequent re-sensitization. Therefore, the development of biomaterials possessing localized healing and antibacterial properties is imperative. In recent years, metal-based biomaterials have emerged as a hot research topic in the management of osteomyelitis due to their inherent antibacterial and bactericidal characteristics. This article provides an overview of the benefits and applications of metal-based biomaterials in treating osteomyelitis, encompassing magnesium-based, iron-based, copper-based, and noble metal–based materials as well as other metallic biomaterials. Metal-based biomaterials exhibit remarkable potential for addressing osteomyelitis owing to their broad-spectrum antibacterial properties, biodegradability, and ability to promote the proliferation of osteoblasts. Furthermore, these materials are gradually being employed in various biomedical therapies such as sonodynamic therapy, microwave dynamic therapy, photodynamic therapy immunotherapy, and multimodal therapy for effective treatment while circumventing the limitations associated with traditional antibiotic approaches. Metal-based biomaterials hold promising prospects for managing osteomyelitis effectively. Further research should focus on exploring solutions pertaining to challenges related to drug resistance, responsible drug release, and impact on mechanical properties of matrices induced by drugs, to facilitate clinical application of metal-based biomaterials in treating osteomyelitis.
期刊介绍：
Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field.
The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest.
Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials.
Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
