Biopharmaceutical drug delivery and phototherapy using protein crystals

IF 15.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2024-11-28 DOI:10.1016/j.addr.2024.115480

Renbin Zhou, Jinghan Qu, Xuejiao Liu, Fangrui Lin, Tymish Y. Ohulchanskyy, Nuernisha Alifu, Junle Qu, Da-Chuan Yin

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Abstract

Biopharmaceutical drugs, including proteins, peptides, and antibodies, are renowned for their high specificity and efficacy, fundamentally transforming disease treatment paradigms. However, their structural complexity presents challenges for their formulation and delivery. Protein crystals, characterized by high purity, high stability and a porous structure for biopharmaceutical drug encapsulation, providing a potential avenue for formulating and delivering biopharmaceutical drugs. There is increasing interest in engineering protein crystals to delivery biopharmaceutical drugs for biomedical applications. This review summarizes the recent advances in biopharmaceutical drug delivery and phototherapy using protein crystals. First, we evaluate the advantages of using protein crystals for biopharmaceutical drugs delivery. Next, we outline the strategies for in vitro and in vivo crystallization to prepare protein crystals. Importantly, the review highlights the advanced applications of protein crystals in biopharmaceutical drug delivery, tumor phototherapy, and other optical fields. Finally, it provides insights into future perspectives of biopharmaceutical drug delivery using protein crystals. This comprehensive review aims to provide effective insights into design of protein crystals to simplify biopharmaceutical drug delivery and improve disease treatment.

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利用蛋白质晶体进行生物制药给药和光疗

生物制药药物（包括蛋白质、肽和抗体）以其高度特异性和疗效而著称，从根本上改变了疾病治疗模式。然而，其结构的复杂性给药物的配制和输送带来了挑战。蛋白质晶体具有高纯度、高稳定性和多孔结构等特点，可用于生物制药药物的封装，为生物制药药物的配制和输送提供了一条潜在的途径。人们对利用蛋白质晶体工程技术为生物医学应用输送生物制药药物的兴趣与日俱增。本综述总结了利用蛋白质晶体进行生物制药给药和光疗的最新进展。首先，我们评估了使用蛋白质晶体输送生物制药药物的优势。接着，我们概述了体外和体内结晶制备蛋白质晶体的策略。重要的是，这篇综述强调了蛋白质晶体在生物制药给药、肿瘤光疗和其他光学领域的先进应用。最后，综述还对使用蛋白质晶体进行生物制药给药的未来前景进行了展望。这篇全面的综述旨在为简化生物制药给药和改善疾病治疗提供有效的蛋白质晶体设计见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.