HPV-Associated Head and Neck Second Primary Tumors-A Case Series.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-11-27 DOI:10.1002/hed.28018

Shimrit Sharav, Joshua D Horton, Zachary Theodossiou, John Turner, David Neskey, Terry Day

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引用次数: 0

Abstract

Background: There is limited understanding of head and neck second primary tumors (SPTs) in HPV-associated squamous cell carcinoma (SCC). Analogous to the concept of field cancerization of the upper airway known to contribute to the development of smoking-related head and neck SPTs, this case series reports four cases of HPV-associated SPTs.

Methods: We reviewed the charts of four patients diagnosed with HPV-associated oropharyngeal SCC who subsequently developed HPV-associated SPTs. Clinical data was collected, including demographics, tumor characteristics, time elapsed between the two diagnoses, and treatment type.

Results: The average age of the patients was 68 years. All of the patients were non-smokers, and none reported heavy alcohol use. All patients had the first cancer in the oropharynx. The time between the first and second diagnoses ranged from 3 and 12 years.

Conclusion: HPV has not been previously identified as a risk factor for head and neck SPTs. Given the long period between the first and second cancers and the lack of other risk factors for head and neck cancer, our case series demonstrates HPV-associated head and neck SPTs.

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HPV相关头颈部第二原发肿瘤--病例系列。

背景：人们对HPV相关鳞状细胞癌（SCC）的头颈部第二原发肿瘤（SPT）了解有限。已知上呼吸道野癌化是导致与吸烟相关的头颈部第二原发肿瘤（SPT）发生的原因，与此概念类似，本病例系列报告了四例与 HPV 相关的第二原发肿瘤：我们查阅了四例被诊断为HPV相关口咽SCC患者的病历，这些患者随后发展为HPV相关SPTs。我们收集了临床数据，包括人口统计学、肿瘤特征、两次诊断之间的时间间隔以及治疗类型：结果：患者的平均年龄为 68 岁。所有患者均不吸烟，无一人酗酒。所有患者的首次癌症都发生在口咽部。首次诊断与第二次诊断之间的时间间隔为 3 年至 12 年不等：结论：HPV 之前尚未被确定为头颈部 SPT 的风险因素。鉴于第一次和第二次癌症之间的间隔时间较长，且缺乏头颈部癌症的其他风险因素，我们的病例系列显示了与人乳头瘤病毒相关的头颈部 SPT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.