Case-Control Study of Cervicovaginal β/γ-Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer.

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI:10.1093/infdis/jiae588

Howard D Strickler, Mykhaylo Usyk, Isam-Eldin Eltoum, Natalie Bachman, Nancy A Hessol, Lisa Flowers, Lisa Rahangdale, Jessica M Atrio, Catalina Ramirez, Howard Minkoff, Adaora A Adimora, Igho Ofotokun, Marla J Keller, Margaret Fischl, Sadeep Shrestha, Rodney Wright, Gypsyamber D'Souza, Lorraine Sanchez-Keeland, Xianhong Xie, Xiaonan Xue, Kathryn Anastos, L Stewart Massad, Joel M Palefsky, Robert D Burk

{"title":"Case-Control Study of Cervicovaginal β/γ-Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer.","authors":"Howard D Strickler, Mykhaylo Usyk, Isam-Eldin Eltoum, Natalie Bachman, Nancy A Hessol, Lisa Flowers, Lisa Rahangdale, Jessica M Atrio, Catalina Ramirez, Howard Minkoff, Adaora A Adimora, Igho Ofotokun, Marla J Keller, Margaret Fischl, Sadeep Shrestha, Rodney Wright, Gypsyamber D'Souza, Lorraine Sanchez-Keeland, Xianhong Xie, Xiaonan Xue, Kathryn Anastos, L Stewart Massad, Joel M Palefsky, Robert D Burk","doi":"10.1093/infdis/jiae588","DOIUrl":null,"url":null,"abstract":"<p><p>We studied cervicovaginal β/γ-human papillomavirus (HPV) and their relationship to cervical precancer in women with human immunodeficiency virus; having previously reported strong positive associations of β/γ-HPV with incident head and neck cancer in the general population. Case patients (n = 124) had cervical intraepithelial neoplasia (CIN) 3 or 2. Controls (n = 247) were individually matched 2:1 to case patients. Unexpectedly, multivariate analyses found strong inverse associations between β/γ-HPV and CIN-2/3 (odds ratio, 0.19 [95% confidence interval, .04-.86]; P = .03; Ptrend < .01]). This is, to our knowledge, the first study of β/γ-HPV and cervical precancer. If confirmed, a strong inverse (protective) association would be of potential clinical and biologic relevance.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"595-599"},"PeriodicalIF":5.0000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911781/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/infdis/jiae588","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

We studied cervicovaginal β/γ-human papillomavirus (HPV) and their relationship to cervical precancer in women with human immunodeficiency virus; having previously reported strong positive associations of β/γ-HPV with incident head and neck cancer in the general population. Case patients (n = 124) had cervical intraepithelial neoplasia (CIN) 3 or 2. Controls (n = 247) were individually matched 2:1 to case patients. Unexpectedly, multivariate analyses found strong inverse associations between β/γ-HPV and CIN-2/3 (odds ratio, 0.19 [95% confidence interval, .04-.86]; P = .03; Ptrend < .01]). This is, to our knowledge, the first study of β/γ-HPV and cervical precancer. If confirmed, a strong inverse (protective) association would be of potential clinical and biologic relevance.

查看原文本刊更多论文

艾滋病女性宫颈阴道 Beta-/Gamma-HPV 感染及其与宫颈癌前病变关系的病例对照研究。

我们研究了宫颈阴道β-/γ-人乳头状瘤病毒（HPV）及其与感染艾滋病毒妇女（WWH）宫颈癌前病变的关系；此前曾有报道称，在普通人群中，β-/γ-HPV与头颈癌的发生呈强正相关。病例（N=124）为宫颈上皮内瘤变（CIN）-3 或 CIN-2。对照组（247 人）与病例进行了 2:1 的单独匹配。出乎意料的是，多变量分析发现，β-/γ-HPV 与 CIN-2/CIN-3 之间存在很强的反向关系（OR=0.19；95% CI 0.04-0.86；P=0.03），Ptrend

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.