Cyanophage Engineering for Algal Blooms Control.

IF 3.8 3区 医学 Q2 VIROLOGY
Viruses-Basel Pub Date : 2024-11-06 DOI:10.3390/v16111745
Yujing Guo, Xiaoxiao Dong, Huiying Li, Yigang Tong, Zihe Liu, Jin Jin
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引用次数: 0

Abstract

Cyanobacteria represent a prevalent category of photosynthetic autotrophs capable of generating deleterious algal blooms, commonly known as cyanobacteria harmful algal blooms (cyanoHABs). These blooms often produce cyanotoxins, which pose risks to public health and ecosystems by contaminating surface waters and drinking water sources. Traditional treatment methods have limited effectiveness. Therefore, there is an urgent need for a new approach to effectively manage cyanoHABs. One promising approach is the use of cyanophages, which are viruses that specifically target cyanobacteria. Cyanophages serve as an effective biological control method for reducing cyanoHABs in aquatic systems. By engineering cyanophages, it is possible to develop a highly specific control strategy that minimally impacts non-target species and their propagation in the environment. This review explores the potential application of cyanophages as a strategy for controlling cyanoHABs. It includes the identification and isolation of broad-spectrum and novel cyanophages, with a specific focus on freshwater Microcystis cyanophages, highlighting their broad spectrum and high efficiency. Additionally, recent advancements in cyanophage engineering are discussed, including genome modification, functional gene identification, and the construction of artificial cyanophages. Furthermore, the current state of application is addressed. Cyanophage is a promising control strategy for effectively managing cyanoHABs in aquatic environments.

控制藻华的噬蓝藻工程。
蓝藻是一种普遍的光合自养生物,能够产生有害的藻华,通常称为蓝藻有害藻华(cyanoHABs)。这些藻华通常会产生蓝藻毒素,污染地表水和饮用水源,从而对公众健康和生态系统造成危害。传统的处理方法效果有限。因此,迫切需要一种新的方法来有效管理蓝藻水华。噬蓝藻病毒是一种专门针对蓝藻的病毒,是一种很有前景的方法。噬蓝藻病毒是一种有效的生物控制方法,可减少水生系统中的蓝藻水华。通过对噬菌体进行工程改造,有可能开发出一种高度特异性的控制策略,对非目标物种及其在环境中的繁殖影响最小。本综述探讨了噬菌体作为一种控制蓝藻水华的策略的潜在应用。其中包括对广谱和新型噬蓝体的鉴定和分离,重点关注淡水微囊藻噬蓝体,突出其广谱性和高效性。此外,还讨论了蓝藻噬菌体工程学的最新进展,包括基因组改造、功能基因鉴定和人工蓝藻噬菌体的构建。此外,还讨论了当前的应用状况。噬蓝藻病毒是一种很有前途的控制策略,可有效治理水生环境中的蓝藻水华。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Viruses-Basel
Viruses-Basel VIROLOGY-
CiteScore
7.30
自引率
12.80%
发文量
2445
审稿时长
1 months
期刊介绍: Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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