Association between metabolic syndrome and chronic obstructive pulmonary disease development in young individuals: a nationwide cohort study.

IF 5.8 2区医学 Q1 Medicine

Respiratory Research Pub Date : 2024-11-26 DOI:10.1186/s12931-024-03038-z

Ock-Hwa Kim, Kyu Na Lee, Kyungdo Han, In Young Cho, Dong Wook Shin, Sei Won Lee

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引用次数: 0

Abstract

Background: The association between metabolic syndrome (MetS) and chronic obstructive pulmonary disease (COPD) has not been studied well, particularly in young individuals. We investigated the risk of COPD development in young individuals based on MetS and its components.

Methods: We used the Korean National Health Information Database to identify 6,891,400 individuals aged 20-39 years who participated in the national health check-up service between 2009 and 2012. Then, we identified individuals with MetS and investigated COPD development based on health insurance claims. Cox proportional hazard regression models were used to calculate the adjusted hazard ratio (aHR) for the risk of COPD development.

Results: During a mean follow-up period of 8.35 years, 13,784 individuals were newly diagnosed with COPD. MetS was associated with an increased risk of COPD (aHR, 1.18; 95% confidence interval [CI], 1.11-1.24). Among the MetS components, except for hyperglycemia, abdominal obesity (aHR, 1.27; 95% CI, 1.19-1.34), hypertension (aHR, 1.05; 95% CI, 1.01-1.10), hypertriglyceridemia (aHR, 1.11; 95% CI, 1.07-1.16), and low high-density lipoprotein cholesterol levels (aHR, 1.16; 95% CI, 1.11-1.22) were significantly associated with COPD development. A higher number of MetS components correlated with an increased risk of COPD development, with the highest risk observed when all five MetS components were present (aHR, 1.55; 95% CI, 1.28-1.87).

Conclusion: MetS was associated with COPD development in young individuals. The risk of COPD development increased along with the increasing number of MetS components. These findings suggest that careful monitoring for COPD development is necessary in young individuals with MetS, especially those with multiple components of MetS.

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年轻人代谢综合征与慢性阻塞性肺病发展之间的关系：一项全国性队列研究。

背景：代谢综合征（MetS）与慢性阻塞性肺疾病（COPD）之间的关系尚未得到充分研究，尤其是在年轻人中。我们根据 MetS 及其组成成分调查了年轻人患慢性阻塞性肺病的风险：方法：我们利用韩国国民健康信息数据库，识别了 2009 年至 2012 年期间参加国民健康检查服务的 689.14 万名 20-39 岁的人。然后，我们根据健康保险索赔确定了 MetS 患者，并调查了慢性阻塞性肺病的发展情况。我们使用考克斯比例危险回归模型计算慢性阻塞性肺病发病风险的调整危险比（aHR）：结果：在平均 8.35 年的随访期间，13784 人被新诊断为慢性阻塞性肺病。MetS与慢性阻塞性肺病发病风险的增加有关（aHR，1.18；95% 置信区间 [CI]，1.11-1.24）。在 MetS 成分中，除高血糖外，腹部肥胖（aHR，1.27；95% CI，1.19-1.34）、高血压（aHR，1.05；95% CI，1.01-1.10）、高甘油三酯血症（aHR，1.11；95% CI，1.07-1.16）和高密度脂蛋白胆固醇水平低（aHR，1.16；95% CI，1.11-1.22）均与慢性阻塞性肺病的发生显著相关。MetS 成分越多，慢性阻塞性肺病的发病风险越高，当所有五个 MetS 成分都存在时，发病风险最高（aHR，1.55；95% CI，1.28-1.87）：结论：MetS 与年轻人慢性阻塞性肺病的发病有关。结论：MetS 与年轻人慢性阻塞性肺病的发生有关，随着 MetS 成分数量的增加，慢性阻塞性肺病的发生风险也随之增加。这些研究结果表明，对于患有 MetS 的年轻人，尤其是患有多种 MetS 的年轻人，有必要对慢性阻塞性肺病的发展进行仔细监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Research RESPIRATORY SYSTEM-

CiteScore

9.70

自引率

1.70%

发文量

314

审稿时长

4-8 weeks

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.