Mechanical Characterization of Individual Needles in Microneedle Arrays: Factors Affecting Compression Test Results.

IF 4.9 3区 医学 Q1 PHARMACOLOGY & PHARMACY
Yusuke Tsuboko, Hideyuki Sakoda, Yoshihiro Okamoto, Yusuke Nomura, Eiichi Yamamoto
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引用次数: 0

Abstract

Background: This study aims to investigate the impact of test conditions on the results of the compression testing of microneedle arrays (MNAs). Methods: Uniaxial compression tests were conducted on polyglycolic acid-fabricated biodegradable MNAs. Load-displacement curves were obtained for varying conditions, including the number of microneedles (MNs) compressed simultaneously, compression speeds, and compression angles. Subsequently, the buckling load and stiffness were calculated, and the MN deformation during compression was observed. Results: The buckling load and stiffness per MN decreased significantly with a simultaneous increase in compressed MNs. The mean buckling load and stiffness of 52 MNs in single-needle compression tests were 0.211 ± 0.008 N and 13.9 ± 1.3 N/mm, respectively, with no variation among the three MNAs. However, a significant difference in buckling load and stiffness was observed among the MNs within the MNAs. Additionally, buckling loads and stiffnesses were significantly lower in certain MNs at the same location in different MNAs. Buckling load and stiffness decreased significantly during inclined compression compared to during vertical compression. While the tests evaluate the mechanical properties of MNAs, test results may vary depending on test conditions. Conclusions: Compression testing of the individual MNs comprising an MNA helps evaluate the mechanical properties of MNs and ensure the quality of MNAs.

微针阵列中单个针头的机械特性分析:影响压缩测试结果的因素
背景:本研究旨在探讨测试条件对微针阵(MNA)压缩测试结果的影响。方法:对聚乙二醇纤维板进行单轴压缩试验:对聚乙二醇酸制成的可生物降解微针阵列进行单轴压缩试验。在不同条件下,包括同时压缩的微针(MN)数量、压缩速度和压缩角度,获得了载荷-位移曲线。随后,计算了屈曲载荷和刚度,并观察了压缩过程中 MN 的变形。结果随着压缩 MN 的同时增加,每个 MN 的屈曲载荷和刚度明显降低。在单针压缩试验中,52 个 MN 的平均屈曲载荷和刚度分别为 0.211 ± 0.008 N 和 13.9 ± 1.3 N/mm,三种 MNA 之间没有差异。然而,在 MNA 中的 MN 之间,屈曲载荷和刚度存在明显差异。此外,不同 MNA 中同一位置的某些 MN 的屈曲载荷和刚度明显较低。与垂直压缩相比,倾斜压缩时的屈曲载荷和刚度明显降低。虽然测试评估的是 MNA 的机械性能,但测试结果可能因测试条件而异。结论:对构成 MNA 的单个 MN 进行压缩测试有助于评估 MN 的机械特性,确保 MNA 的质量。
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来源期刊
Pharmaceutics
Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.90
自引率
11.10%
发文量
2379
审稿时长
16.41 days
期刊介绍: Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications,  and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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