Spectrum of Craniofacial and Oral Malformations in China, a Multicenter Study.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-11-27 DOI:10.1111/odi.15207

Xiaohong Duan, Yulong Zhu, Shuguo Zheng, Yaling Song, Wenmei Wang, Dong Chen, Zhenjin Zhao, Yongchu Pan, Zhuo Chen, Tingting Zhang, Yongqing Huang, Liling Ren, Dandan Ma, Weihong Wang, Shengbin Huang, Qinggao Song, Baisheng Wang, Yan Zheng, Jiang Li, Jianhua Wang, Yanli Zhang, Xinyue Guo, Wenyan Ruan, Jing Wang, Zhongcheng Gong, Xiaofeng Chang, Zhenglin Yuan, Fu Wang, Guangqing Tian, Jing Meng, Zhexuan Bao, Lin Li

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引用次数: 0

Abstract

Objective: Craniofacial and oral malformations (COMs) represent an important class of human developmental disorders with profound implications on the anatomical structure, appearance, and various physiological functions. In this study, we aimed to define the spectrum of COMs and analysis its features or possible influencing factors to improve the surveillance and control of the disease.

Materials and methods: We organized a multicenter survey of COMs from 19 hospitals in 14 provinces. The clinical data of COM cases were collected from the electronic medical records system, cleaned and aggregated for analysis.

Results: A total of 90,895 COM cases with 76 types of diseases were identified from 34,649,545 hospital population. The four most common COMs were supernumery teeth (62.64%), cleft lip and palate (28.53%), microdontia (2.86%), and tooth agenesis (1.70%). The remaining 72 diseases were detected in 3881 cases and were considered to be rare COMs. Moreover, 84.72% of rare COMs also manifested as other malformations or dysfunctions of the bone, skin and other tissues.

Conclusions: COMs exhibit age and gender distribution patterns, have multiple types, and significant dental malformations. The diagnostic criteria and registration practices for COMs influence their reported prevalence and temporal trends, necessitating future improvements.

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中国颅面和口腔畸形谱系的多中心研究。

目的：颅面和口腔畸形（COMs）是一类重要的人类发育疾病，对解剖结构、外观和各种生理功能有着深远的影响。在这项研究中，我们旨在界定颅面和口腔畸形的范围，分析其特征或可能的影响因素，以改善对该疾病的监测和控制：我们对 14 个省的 19 家医院的 COMs 病例进行了多中心调查。结果：COM病例的临床数据来自电子病历系统，经清理和汇总后进行分析：结果：从 34,649,545 名住院患者中，共发现 90,895 例 COM，涉及 76 种疾病。最常见的四种疾病分别是上颌畸形（62.64%）、唇腭裂（28.53%）、小颌畸形（2.86%）和牙齿缺失（1.70%）。其余 72 种疾病在 3881 个病例中检出，被认为是罕见的 COMs。此外，84.72%的罕见COM还表现为骨骼、皮肤和其他组织的其他畸形或功能障碍：结论：COMs表现出年龄和性别分布的规律，具有多种类型和明显的牙齿畸形。COM的诊断标准和登记方法会影响其报告的发病率和时间趋势，因此有必要在未来加以改进。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.