Recent Advances of PDMS In Vitro Biomodels for Flow Visualizations and Measurements: From Macro to Nanoscale Applications.

IF 3 3区工程技术 Q2 CHEMISTRY, ANALYTICAL

Micromachines Pub Date : 2024-10-29 DOI:10.3390/mi15111317

Andrews Souza, Glauco Nobrega, Lucas B Neves, Filipe Barbosa, João Ribeiro, Conrado Ferrera, Rui A Lima

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引用次数: 0

Abstract

Polydimethylsiloxane (PDMS) has become a popular material in microfluidic and macroscale in vitro models due to its elastomeric properties and versatility. PDMS-based biomodels are widely used in blood flow studies, offering a platform for improving flow models and validating numerical simulations. This review highlights recent advances in bioflow studies conducted using both PDMS microfluidic devices and macroscale biomodels, particularly in replicating physiological environments. PDMS microchannels are used in studies of blood cell deformation under confined conditions, demonstrating the potential to distinguish between healthy and diseased cells. PDMS also plays a critical role in fabricating arterial models from real medical images, including pathological conditions such as aneurysms. Cutting-edge applications, such as nanofluid hemodynamic studies and nanoparticle drug delivery in organ-on-a-chip platforms, represent the latest developments in PDMS research. In addition to these applications, this review critically discusses PDMS properties, fabrication methods, and its expanding role in micro- and nanoscale flow studies.

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用于流动可视化和测量的 PDMS 体外生物模型的最新进展：从宏观到纳米级应用。

聚二甲基硅氧烷（PDMS）因其弹性体特性和多功能性，已成为微流控和宏观体外模型的常用材料。基于 PDMS 的生物模型广泛应用于血流研究，为改进血流模型和验证数值模拟提供了平台。本综述重点介绍使用 PDMS 微流体设备和宏观生物模型进行生物流研究的最新进展，尤其是在复制生理环境方面。PDMS 微通道用于研究封闭条件下的血细胞变形，显示了区分健康细胞和病变细胞的潜力。PDMS 在根据真实医学影像制作动脉模型（包括动脉瘤等病理情况）方面也发挥着至关重要的作用。纳米流体血流动力学研究和器官芯片平台中的纳米粒子药物输送等尖端应用代表了 PDMS 研究的最新发展。除这些应用外，本综述还对 PDMS 的特性、制造方法及其在微米和纳米级流动研究中不断扩大的作用进行了深入探讨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Micromachines NANOSCIENCE & NANOTECHNOLOGY-INSTRUMENTS & INSTRUMENTATION

CiteScore

5.20

自引率

14.70%

发文量

1862

审稿时长

16.31 days

期刊介绍： Micromachines (ISSN 2072-666X) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to micro-scaled machines and micromachinery. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.