Targeting Disulfidptosis with Potentially Bioactive Natural Products in Metabolic Cancer Therapy.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2024-11-08 DOI:10.3390/metabo14110604

Xinyan Li, Jiayi Xu, Liangwen Yan, Shenkang Tang, Yinggang Zhang, Mengjiao Shi, Pengfei Liu

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引用次数: 0

Abstract

Background: Metabolic cancers are defined by metabolic reprogramming. Although this reprograming drives rapid tumour growth and invasion, it also reveals specific metabolic vulnerabilities that can be therapeutically exploited in cancer therapy. A novel form of programmed cell death, known as disulfidptosis, was identified last year; tumour cells with high SLC7A11 expression undergo disulfidptosis when deprived of glucose. Natural products have attracted increasing attention and have shown potential to treat metabolic cancers through diverse mechanisms.

Methods: We systematically searched electronic databases involving PubMed, Web of Science, Gooale Scholar. To ensue comprehensive exploration, keywords including metabolic reprogramming, metabolic cancer, disulfidptosis, natural products and some other words were employed.

Results: In this review, we focus on the shared characteristics and metabolic vulnerabilities of metabolic cancers. Additionally, we discuss the molecular mechanisms underlying disulfidptosis and highlight key regulatory genes. Furthermore, we predict bioactive natural products that target disulfidptosis-related genes, offering new perspectives for anticancer strategies through the modulation of disulfidptosis.

Conclusions: By summarizing current research progress, this review mainly analyzed the potential mechanisms of natural products in the treatment of metabolic cancer.

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在癌症代谢治疗中利用具有潜在生物活性的天然产品靶向二硫化反应

背景：代谢性癌症是由代谢重编程定义的。虽然这种重编程会促使肿瘤快速生长和侵袭，但它也揭示了特定的代谢漏洞，可在癌症治疗中加以利用。去年发现了一种新的细胞程序性死亡形式，即二硫化硫；SLC7A11高表达的肿瘤细胞在缺乏葡萄糖的情况下会发生二硫化硫。天然产品引起了越来越多的关注，并显示出通过不同机制治疗代谢性癌症的潜力：我们系统地检索了 PubMed、Web of Science 和 Gooale Scholar 等电子数据库。为了进行全面探索，我们使用了包括代谢重编程、代谢性癌症、二硫化硫、天然产品等关键词：在这篇综述中，我们重点讨论了代谢性癌症的共同特征和代谢脆弱性。此外，我们还讨论了二硫化过程的分子机制，并重点介绍了关键的调控基因。此外，我们还预测了以二硫化硫相关基因为靶点的生物活性天然产物，为通过调节二硫化硫的抗癌策略提供了新的视角：本综述通过总结目前的研究进展，主要分析了天然产物治疗代谢性癌症的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.