Systematic Review and Meta-Analysis of Sclerocarya birrea on Metabolic Disorders: Evidence from Preclinical Studies.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2024-11-12 DOI:10.3390/metabo14110615

Desirée Victoria-Montesinos, Pura Ballester, Pablo Barcina-Pérez, Ana María García-Muñoz

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引用次数: 0

Abstract

Background/objectives: Metabolic disorders, including diabetes, obesity, and cardiovascular diseases, are significant global health issues. Nutraceuticals, such as Sclerocarya birrea (SB), known for its high polyphenol content, are increasingly explored for managing these conditions. This study aims to evaluate the antihyperglycemic, hypolipidemic, and antihypertensive effects of SB in animal models to understand its potential as a natural intervention for metabolic diseases.

Methods: A systematic review and meta-analysis were conducted according to PRISMA guidelines. Searches across databases like PubMed, Web of Science, Embase, and Scopus identified studies using SB in animal models of metabolic disorders. Inclusion criteria were studies with SB intervention, control groups, and quantitative measures of metabolic parameters. The study was registered with INPLASY (INPLASY2024100031).

Results: The meta-analysis revealed that SB significantly reduces blood glucose levels in diabetic animal models. Acute administration of SB showed a pooled standardized mean difference (SMD) of -7.13 (95% CI: -11.44 to -2.83) at 1 h and -9.75 (95% CI: -15.92 to -3.59) at 2-4 h post-administration. Chronic administration indicated a non-significant reduction in glucose levels (SMD: -5.69, 95% CI: -16.38 to 5.01).

Conclusions: SB appears to have the potential for reducing blood glucose levels and may offer benefits for other cardiometabolic risk factors, including lipid profiles and oxidative stress. However, variability in the results underscores the need for further research, including standardized animal studies and clinical trials, to confirm these effects and clarify the mechanisms by which SB may impact metabolic disorders.

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系统综述和元分析：硬骨蕨对代谢紊乱的影响：临床前研究的证据。

背景/目标：代谢紊乱，包括糖尿病、肥胖症和心血管疾病，是重大的全球健康问题。营养保健品，如以多酚含量高而著称的 Sclerocarya birrea（SB），越来越多地被用于控制这些疾病。本研究旨在评估 SB 在动物模型中的降血糖、降血脂和降血压作用，以了解其作为代谢性疾病天然干预措施的潜力：方法：根据 PRISMA 指南进行了系统综述和荟萃分析。通过对 PubMed、Web of Science、Embase 和 Scopus 等数据库的检索，确定了在代谢紊乱动物模型中使用 SB 的研究。纳入标准是有 SB 干预、对照组和代谢参数定量测量的研究。该研究已在 INPLASY（INPLASY2024100031）上注册：荟萃分析表明，SB 能显著降低糖尿病动物模型的血糖水平。急性给药显示，给药后 1 小时和 2-4 小时的汇总标准化平均差（SMD）分别为-7.13（95% CI：-11.44 至 -2.83）和-9.75（95% CI：-15.92 至 -3.59）。长期用药后，血糖水平下降不明显（SMD：-5.69，95% CI：-16.38 至 5.01）：SB似乎具有降低血糖水平的潜力，并可能对其他心脏代谢风险因素（包括血脂状况和氧化应激）有益。然而，研究结果的不一致性强调了进一步研究的必要性，包括标准化的动物研究和临床试验，以证实这些效果并阐明沙丁鱼可能影响代谢紊乱的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.