Serum Irisin, Myostatin, and Myonectin Correlate with Metabolic Health Markers, Liver Disease Progression, and Blood Pressure in Patients with Metabolic Dysfunction-Associated Fatty Liver Disease and Hypertension.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2024-10-28 DOI:10.3390/metabo14110584

Anna F Sheptulina, Elvira M Mamutova, Anastasia Yu Elkina, Yuriy S Timofeev, Victoria A Metelskaya, Anton R Kiselev, Oxana M Drapkina

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引用次数: 0

Abstract

Background/objectives: Recent data indicate the involvement of skeletal muscles in the regulation of metabolism and in the pathogenesis of chronic noncommunicable diseases. The goal of our study was to describe the serum concentrations of myokines in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and hypertension (HTN) and their correlation with laboratory parameters, blood pressure (BP), and MASLD severity.

Methods: A total of 67 patients with MASLD and HTN underwent anthropometric measurements, laboratory tests, and point shear-wave elastography. The serum concentrations of myokines were measured using enzyme-linked immunosorbent assay (ELISA).

Results: Patients with detectable serum myonectin concentrations had significantly higher maximum systolic blood pressure (p = 0.022) and higher blood levels of uric acid (p = 0.029). Serum irisin concentration ≥ 6.1 μg/mL was associated with higher FLI values (p = 0.042) and liver stiffness (p = 0.034), as well as with slightly higher waist circumference (p = 0.082) and triglyceride level (p = 0.062). Patients with serum myostatin concentration ≥ 4.98 ng/mL were significantly older (p = 0.033) and had a lower blood albumin level (p = 0.043).

Conclusions: In conclusion, the myokine profile in patients with MASLD and HTN correlates both with the severity of MASLD and the parameters characteristic of metabolic health, suggesting the possible contribution of altered irisin, myonectin, and myostatin concentrations to the occurrence of cardiometabolic risks in patients with MASLD.

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代谢功能障碍相关性脂肪肝和高血压患者血清鸢尾素、肌促蛋白和肌连蛋白与代谢健康标志物、肝病进展和血压的关系

背景/目的：最近的数据表明，骨骼肌参与了新陈代谢的调节和慢性非传染性疾病的发病机制。我们的研究旨在描述代谢功能障碍相关性脂肪肝（MASLD）和高血压（HTN）患者血清中肌动蛋白的浓度及其与实验室参数、血压（BP）和MASLD严重程度的相关性：共有 67 名 MASLD 和高血压患者接受了人体测量、实验室检查和点剪切波弹性成像检查。采用酶联免疫吸附试验（ELISA）测定血清中肌动蛋白的浓度：结果：检测到血清肌动蛋白浓度的患者最大收缩压明显升高（p = 0.022），血尿酸水平升高（p = 0.029）。血清鸢尾素浓度≥6.1 μg/mL与较高的FLI值（p = 0.042）和肝僵硬度（p = 0.034）有关，也与稍高的腰围（p = 0.082）和甘油三酯水平（p = 0.062）有关。血清肌动蛋白浓度≥4.98纳克/毫升的患者年龄明显偏大（p = 0.033），血白蛋白水平较低（p = 0.043）：总之，MASLD 和高血压患者的肌动蛋白谱与 MASLD 的严重程度和代谢健康的特征参数相关，这表明鸢尾素、肌连蛋白和肌生长因子浓度的改变可能是导致 MASLD 患者发生心脏代谢风险的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.