Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria Model.

IF 5 3区医学 Q1 ENGINEERING, BIOMEDICAL

Journal of Functional Biomaterials Pub Date : 2024-11-06 DOI:10.3390/jfb15110331

Bounghoon Lee, Hyunsuk Choi, Dong-Seok Sohn

引用次数: 0

Abstract

This study evaluated the regenerative potential of demineralized dentin-derived matrix (DDM) as a bone graft material in rabbit calvaria. DDM, sourced from extracted teeth, is emerging as an alternative to traditional grafts like allografts and xenografts. We aimed to identify the most effective demineralization protocol to optimize the regenerative capacity of DDM. Four groups were compared: a control group without grafts, a non-demineralized DDM group, and two demineralized DDM groups (15 and 30 min demineralization). Histomorphometric analysis was conducted in a randomized and blinded setting at 2, 4, and 8 weeks post-graft placement. The results revealed that the 15 min demineralized DDM group showed the most significant new bone formation (42.51% ± 6.40% at 8 weeks; p < 0.05), suggesting its potential as a highly effective regenerative graft material.

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用脱矿牙本质移植材料优化骨再生：兔钙化模型中脱矿时间的影响

这项研究评估了脱矿牙本质衍生基质（DDM）作为兔小腿骨移植材料的再生潜力。脱矿牙本质基质来源于拔出的牙齿，正在成为异体移植和异种移植等传统移植材料的替代品。我们的目标是找出最有效的脱矿方案，以优化 DDM 的再生能力。我们对四组进行了比较：没有移植物的对照组、未去矿物质的 DDM 组和两组去矿物质的 DDM 组（分别去矿物质 15 分钟和 30 分钟）。在移植后 2、4 和 8 周，在随机和盲法环境下进行了组织形态计量分析。结果显示，15 分钟去矿化 DDM 组显示出最显著的新骨形成（8 周时为 42.51% ± 6.40%；P < 0.05），表明其具有作为高效再生移植材料的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.