Volumetric Analysis of Motor Cortex and Basal Ganglia in Pediatric Celiac Disease Patients Using volBrain: Implications for Neurological Dysfunction-Preliminary Results.

IF 3 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Diagnostics Pub Date : 2024-11-14 DOI:10.3390/diagnostics14222559

Filip Murn, Lana Loncar, Jasna Lenicek Krleza, Goran Roic, Iva Hojsak, Zrinjka Misak, Ana Tripalo Batos

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引用次数: 0

Abstract

Background/objectives: Celiac disease (CD) is a common immune-mediated, chronic systemic disorder that is treated with a strict, life-long gluten-free diet (GFD). In addition to gastrointestinal manifestations, CD also presents with a variety of extraintestinal symptoms, including significant neurological and neuropsychiatric symptoms. Among these neurological manifestations, motor dysfunctions are particularly notable. The aim of this study is to investigate the potential volumetric differences in brain structures, particularly the motor cortex and basal ganglia, between pediatric CD patients and healthy controls using the volBrain software AssemblyNet version 1.0.

Methods: This prospective study included pediatric patients with CD who complained of neurological symptoms and were scheduled for brain magnetic resonance imaging (MRI). All children had been previously diagnosed with CD and their adherence to GFD was evaluated using the Biagi score. Brain MRIs were performed on all included patients to obtain volumetry at the onset of the disease. For volumetric and segmentation data, the volBrain software was used.

Results: In total, 12 pediatric patients with CD were included, with a median duration of a GFD of 5.3 years at the time of the MRI examination. There were no statistically significant differences between patients compliant with the GFD and those non-compliant in terms of age or duration of GFD. Volumetric analysis revealed deviations in all patients analyzed, which involved either a decrease or increase in the volume of the structures studied.

Conclusion: Despite the limited number of patients in this study, the initial findings support previously described neurological manifestations in patients with CD. Newly developed MRI tools have the potential to enable a more detailed analysis of disease progression and its impact on the motor cortex.

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使用 volBrain 对小儿乳糜泻患者的运动皮层和基底节进行容积分析：初步结果对神经功能障碍的影响

背景/目的：乳糜泻（Celiac disease，CD）是一种常见的免疫介导的慢性全身性疾病，需要通过严格的终身无麸质饮食（GFD）来治疗。除了胃肠道表现外，乳糜泻还会出现各种肠道外症状，包括明显的神经和神经精神症状。在这些神经系统表现中，运动功能障碍尤为突出。本研究的目的是利用 volBrain 软件 AssemblyNet 1.0 版研究儿科 CD 患者和健康对照组之间大脑结构，尤其是运动皮层和基底节的潜在容积差异：这项前瞻性研究纳入了主诉有神经系统症状并计划接受脑磁共振成像（MRI）检查的儿科 CD 患者。所有患儿既往均被诊断为 CD，并使用 Biagi 评分评估了他们对 GFD 的依从性。对所有患者进行了脑磁共振成像检查，以获得发病时的容积测量数据。结果：共纳入了 12 名 CD 儿童患者，磁共振成像检查时的 GFD 中位持续时间为 5.3 年。在年龄和GFD持续时间方面，符合GFD要求的患者与不符合GFD要求的患者之间没有明显的统计学差异。容积分析显示，所有接受分析的患者都出现了偏差，涉及所研究结构容积的减少或增加：尽管这项研究的患者人数有限，但初步研究结果支持之前描述的 CD 患者的神经系统表现。新开发的磁共振成像工具有可能对疾病进展及其对运动皮层的影响进行更详细的分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

4.70

自引率

8.30%

发文量

2699

审稿时长

19.64 days

期刊介绍： Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.