Age as a Predictor of Overall Survival in Colorectal Cancer.

IF 3 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Diagnostics Pub Date : 2024-11-14 DOI:10.3390/diagnostics14222550

Berenice Carbajal-López, Jossimar Coronel-Hernández, Marytere Herrera, Erika Ruiz-Garcia, Sayako M Miyagui-Adame, Consuelo Diaz-Romero, Eduardo Osiris Madrigal-Santillán, Priscila Morales Esponda-Mendoza, Carlos Pérez-Plasencia, Germán Calderillo-Ruiz

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引用次数: 0

Abstract

Background: The diagnosis of colorectal cancer (CRC) at early ages has become a challenging trend for oncology due to high rates of mortality worldwide. The correlation of clinical features with young-age prognosis in CRC remains unclear. Therefore, we aimed to describe the clinicopathological features and their impact on the overall survival of young Mexican adults diagnosed with CRC treated in the National Cancer Institute.

Methods: This was a retrospective, observational study. The included patients were treated at the National Cancer Institute between 2004 and 2020. The statistical analyses comprised the X² and t tests, Kaplan-Meier, log rank, and Cox regression. Statistical significances were assessed when p was bilaterally < 0.05.

Results: A total of 3652 patients diagnosed with CRC attended the National Cancer Institute. Cases of early onset of CRC increased over the 16 years under study, with significant differences between the median age, from 57 in 2004 to 55 years old in 2020 (F = 5.49; gl: 12 p = 0.019). For this analysis, the population was divided in three groups: young (≤30 years), adults (31-70), and elderly (>70). The young population was mostly composed of men (62%; (n = 63), (p = 0.020), with high rates of metastatic disease (44%) (p = 0.001) and right-side tumors (57%), (p = 0.046), and with 44% with a moderate grade (p = 0.750). According to the overall survival (OS) analysis, the median OS was 29 months for young, versus 170 months for adult and 56 months for elderly patients (p <0.001, HR 1.53, 95% CI 1.11-2.10). A sub-analysis was performed considering only patients with metastatic disease. The median OS was 12 months for young, versus 17 and 9 months for adults and elderly (p = 0.08, HR 1.27, 95% CI 1.02-1.46).

Conclusions: CRC diagnosis in the young population is increasing due unhealthy lifestyle habits and lack of screening. This population have clinical features of bad prognosis, such as left side, poor grade differentiation, and metastatic disease, precluding prognosis and OS.

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年龄是结直肠癌患者总生存期的预测因素。

背景：由于全球范围内的高死亡率，早期诊断结直肠癌（CRC）已成为肿瘤学的一个挑战趋势。CRC 的临床特征与年轻预后的相关性仍不清楚。因此，我们旨在描述在墨西哥国家癌症研究所接受治疗的墨西哥年轻成人 CRC 患者的临床病理特征及其对总生存率的影响：这是一项回顾性观察研究。方法：这是一项回顾性观察研究，研究对象为2004年至2020年间在国家癌症研究所接受治疗的患者。统计分析包括 X2 和 t 检验、Kaplan-Meier、对数秩和 Cox 回归。当双侧P均小于0.05时，评估统计意义：结果：共有 3652 名确诊为 CRC 的患者前往美国国家癌症研究所就诊。早发 CRC 病例在研究的 16 年间有所增加，中位年龄从 2004 年的 57 岁到 2020 年的 55 岁之间存在显著差异（F = 5.49；gl：12 p = 0.019）。为了进行分析，人口被分为三组：年轻人（≤30 岁）、成年人（31-70 岁）和老年人（>70 岁）。年轻群体主要由男性组成（62%；（n = 63），（p = 0.020），转移性疾病比例高（44%）（p = 0.001），右侧肿瘤比例高（57%），（p = 0.046），中度分级比例高（44%）（p = 0.750）。根据总生存期（OS）分析，年轻患者的中位OS为29个月，而成年患者为170个月，老年患者为56个月（P = 0.08，HR 1.27，95% CI 1.02-1.46）：结论：由于不健康的生活习惯和缺乏筛查，被诊断为癌症的年轻人越来越多。结论：由于不健康的生活习惯和缺乏筛查，年轻群体中确诊的 CRC 患者越来越多，这些人群具有预后不良的临床特征，如左侧、分化分级差和转移性疾病，从而影响了预后和 OS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

4.70

自引率

8.30%

发文量

2699

审稿时长

19.64 days

期刊介绍： Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.