Creating a Foundation for the Visualization of Intracranial Cerebrospinal Fluid Using Photon-Counting Technology in Spectral Imaging for Cranial CT.

IF 3 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Diagnostics Pub Date : 2024-11-14 DOI:10.3390/diagnostics14222551

Anna Klempka, Philipp Neumayer, Alexander Schröder, Eduardo Ackermann, Svetlana Hetjens, Sven Clausen, Christoph Groden

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Abstract

Background: Recent advancements in computed tomography (CT), notably in photon-counting CT (PCCT), are revolutionizing the medical imaging field. PCCT's spectral imaging can better visualize tissues based on their material properties. This research aims to establish a fundamental approach for the in vivo visualization of intracranial cerebrospinal fluid (CSF) using PCCT.

Methods: PCCT was integrated to distinguish the CSF within the intracranial space with spectral imaging. In this study, we analyzed monoenergetic +67 keV reconstructions alongside virtual non-contrast and iodine phase images. This approach facilitated the assessment of the spectral characteristics of CSF in patients who did not present with intra-axial pathology or inflamation.

Results: Our findings illustrate PCCT's effectiveness in providing distinct and clear visualizations of intracranial CSF structures, building a foundation. The signal-to-noise ratio was quantified across all measurements, to check in image quality.

Conclusions: PCCT serves as a robust, non-invasive platform for the detailed visualization of intracranial CSF. This technology is promising in enhancing diagnostic accuracy through different conditions.

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在头颅 CT 光谱成像中使用光子计数技术为颅内脑脊液可视化奠定基础

背景：计算机断层扫描（CT）的最新进展，尤其是光子计数 CT（PCCT），正在医学成像领域掀起一场革命。PCCT 的光谱成像可以根据组织的材料特性更好地观察组织。本研究旨在利用 PCCT 建立颅内脑脊液（CSF）活体可视化的基本方法：方法：将 PCCT 与光谱成像技术相结合，以区分颅内空间的 CSF。在这项研究中，我们分析了单能 +67 keV 重建以及虚拟非对比和碘相位图像。这种方法有助于评估未出现轴内病变或炎症的患者 CSF 的光谱特征：我们的研究结果表明，PCCT 能有效提供颅内 CSF 结构的清晰图像，并为其奠定基础。我们对所有测量的信噪比进行了量化，以检查图像质量：PCCT 是一种强大的无创平台，可用于颅内 CSF 的详细成像。该技术有望提高不同情况下的诊断准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

4.70

自引率

8.30%

发文量

2699

审稿时长

19.64 days

期刊介绍： Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.